| dc.contributor.author |
Kokotos, G |
en |
| dc.contributor.author |
ConstantinouKokotou, V |
en |
| dc.contributor.author |
Noula, C |
en |
| dc.contributor.author |
Nicolaou, A |
en |
| dc.contributor.author |
Gibbons, WA |
en |
| dc.date.accessioned |
2014-06-06T06:43:04Z |
|
| dc.date.available |
2014-06-06T06:43:04Z |
|
| dc.date.issued |
1996 |
en |
| dc.identifier.issn |
0367-8377 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/995 |
|
| dc.subject |
dipeptide alcohol |
en |
| dc.subject |
human platelet phospholipase A(2) |
en |
| dc.subject |
lipidic amino acid |
en |
| dc.subject |
lipidic peptide |
en |
| dc.subject |
phospholipase A(2) inhibitors |
en |
| dc.subject |
synthesis |
en |
| dc.subject.classification |
Biochemistry & Molecular Biology |
en |
| dc.subject.other |
COMPETITIVE-INHIBITION |
en |
| dc.subject.other |
ANALOGS |
en |
| dc.subject.other |
PEPTIDES |
en |
| dc.subject.other |
ENZYMES |
en |
| dc.subject.other |
CONVERSION |
en |
| dc.title |
Synthesis of lipidic amino acid and dipeptide inhibitors of human platelet phospholipase A(2) |
en |
| heal.type |
journalArticle |
en |
| heal.language |
English |
en |
| heal.publicationDate |
1996 |
en |
| heal.abstract |
Phospholipases A(2) (PLA(2)s) catalyze the hydrolysis of glycerophospholipids at the sn-2 position, and their inhibition is considered a rational approach for the prevention and treatment of inflammation. A number of amides and esters of alpha-amino acids with saturated linear side chains, esters of alpha-amino alcohols and derivatives of lipidic peptides were prepared and tested against secreted humal platelet phospholipase A(2). Among the compounds tested the amides of free amino acids with long-chain amines presented the highest in vitro inhibitory activity. (C) Munksgaard 1996. |
en |
| heal.publisher |
MUNKSGAARD INT PUBL LTD |
en |
| heal.journalName |
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH |
en |
| dc.identifier.issue |
2 |
en |
| dc.identifier.volume |
48 |
en |
| dc.identifier.isi |
ISI:A1996VE32200008 |
en |
| dc.identifier.spage |
160 |
en |
| dc.identifier.epage |
166 |
en |