dc.contributor.author |
Kokotos, G |
en |
dc.contributor.author |
Constantinou-Kokotou, V |
en |
dc.date.accessioned |
2014-06-06T06:43:03Z |
|
dc.date.available |
2014-06-06T06:43:03Z |
|
dc.date.issued |
1996 |
en |
dc.identifier.issn |
03678377 |
en |
dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/984 |
|
dc.relation.uri |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029747138&partnerID=40&md5=2a38ece305dba409fcaa6b8927cd9b36 |
en |
dc.subject |
Dipeptide alcohol |
en |
dc.subject |
Human platelet phospholipase A2 |
en |
dc.subject |
Lipid amino acid |
en |
dc.subject |
Lipidic peptide |
en |
dc.subject |
Phospholipase A2 inhibitors |
en |
dc.subject |
Synthesis |
en |
dc.subject.other |
2 amino n hexadecylhexadecanamide |
en |
dc.subject.other |
2 amino n hexadecylhexanamide |
en |
dc.subject.other |
amino acid derivative |
en |
dc.subject.other |
phospholipase a2 |
en |
dc.subject.other |
phospholipase inhibitor |
en |
dc.subject.other |
unclassified drug |
en |
dc.subject.other |
article |
en |
dc.subject.other |
controlled study |
en |
dc.subject.other |
drug synthesis |
en |
dc.subject.other |
enzyme activity |
en |
dc.subject.other |
human |
en |
dc.subject.other |
human cell |
en |
dc.subject.other |
in vitro study |
en |
dc.subject.other |
structure activity relation |
en |
dc.subject.other |
thrombocyte |
en |
dc.subject.other |
Amino Acids |
en |
dc.subject.other |
Blood Platelets |
en |
dc.subject.other |
Dipeptides |
en |
dc.subject.other |
Enzyme Inhibitors |
en |
dc.subject.other |
Humans |
en |
dc.subject.other |
Magnetic Resonance Spectroscopy |
en |
dc.subject.other |
Phosphatidic Acids |
en |
dc.subject.other |
Phospholipases A |
en |
dc.subject.other |
Spectrometry, Mass, Fast Atom Bombardment |
en |
dc.title |
Synthesis of lipidic amino acid and dipeptide inhibitors of human platelet phospholipase A2 |
en |
heal.type |
journalArticle |
en |
heal.publicationDate |
1996 |
en |
heal.abstract |
Phospholipases A2 (PLA2s) catalyze the hydrolysis of glycerophospholipids at the sn-2 position, and their inhibition is considered a rational approach for the prevention and treatment of inflammation. A number of amides and esters of α-amino acids with saturated linear side chains, esters of α-amino alcohols and derivatives of lipidic peptides were prepared and tested against secreted human platelet phospholipase A2. Among the compounds tested the amides of free amino acids with long-chain amines presented the highest in vitro inhibitory activity. |
en |
heal.journalName |
International Journal of Peptide and Protein Research |
en |
dc.identifier.issue |
2 |
en |
dc.identifier.volume |
48 |
en |
dc.identifier.spage |
160 |
en |
dc.identifier.epage |
166 |
en |