Total synthesis of natural (-)-combretastatin D-1

dc.contributor.author	Couladouros, EA	en
dc.contributor.author	Soufli, IC	en
dc.date.accessioned	2014-06-06T06:42:59Z
dc.date.available	2014-06-06T06:42:59Z
dc.date.issued	1995	en
dc.identifier.issn	00404039	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/931
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0028822734&partnerID=40&md5=af45f9b44561d69121a17d064582d5cf	en
dc.subject.other	antineoplastic agent	en
dc.subject.other	combretastatin d1	en
dc.subject.other	macrocyclic compound	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	drug synthesis	en
dc.subject.other	reaction analysis	en
dc.subject.other	stereochemistry	en
dc.title	Total synthesis of natural (-)-combretastatin D-1	en
heal.type	journalArticle	en
heal.publicationDate	1995	en
heal.abstract	Combretastatin D-1, (2), was synthesized via a 12 step sequence. Sharpless asymmetric dihydroxylation was used in order to introduce the appropriate asymmetry. Regiospecific cyclodehydration of the diol 3 gave the title compound in 96% ee.	en
heal.journalName	Tetrahedron Letters	en
dc.identifier.issue	51	en
dc.identifier.volume	36	en
dc.identifier.spage	9369	en
dc.identifier.epage	9372	en