Linking Chronic Infection and Autoimmune Diseases: Mycobacterium avium Subspecies paratuberculosis, SLC11A1 Polymorphisms and Type1 Diabetes Mellitus

dc.contributor.advisor	Paccagnini, Daniela	it
dc.contributor.author	Sieswerda, Lee	en
dc.contributor.author	Rosu, Valentina	it
dc.contributor.author	Masala, Speranza	it
dc.contributor.author	Pacifico, Adolfo	it
dc.contributor.author	Gazouli, Maria	en
dc.contributor.author	Γκαζούλη, Μαρία	el
dc.contributor.author	Οικονομόπουλος, Ιωάννης Α.	el
dc.contributor.author	Ikonomopoulos, John A.	en
dc.contributor.author	Ahmed, Niyaz	en
dc.contributor.author	Zanetti, Stefania	it
dc.contributor.author	Sechi, Leonardo A.	it
dc.date.accessioned	2015-08-31T12:09:44Z
dc.date.available	2015-08-31T12:09:44Z
dc.date.issued	2009-09-21
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/6409
dc.identifier.uri	http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007109
dc.rights	CC0 1.0 Παγκόσμια	*
dc.rights.uri	http://creativecommons.org/publicdomain/zero/1.0/	*
dc.title	Linking Chronic Infection and Autoimmune Diseases: Mycobacterium avium Subspecies paratuberculosis, SLC11A1 Polymorphisms and Type1 Diabetes Mellitus	en
heal.type	journalArticle
heal.keyword	Chronic infection	en
heal.keyword	Autoimmune diseases	en
heal.keyword	Genetic polymorphism	en
heal.keyword	Diabetes mellitus	en
heal.identifier.secondary	http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007109
heal.access	free
heal.recordProvider	Γεωπονικό Πανεπιστήμιο Αθηνών/Ζωική Παραγωγή	el
heal.recordProvider	University of Sassari/Dipartimento di Scienze Biomediche	en
heal.recordProvider	University of Hyderabad/Department of Biotechnology	en
heal.recordProvider	Πανεπιστήμιο Αθηνών/Ιατρική Σχολή	el
heal.publicationDate	2009-09-21
heal.bibliographicCitation	Paccagnini, Daniela, Linking Chronic Infection and Autoimmune Diseases: Mycobacterium avium Subspecies paratuberculosis, SLC11A1 Polymorphisms and Type1 Diabetes Mellitus, Plos One, vol. 4 (9), pp 1-4, PLOS, 2009	en
heal.abstract	The etiology of type 1 diabetes mellitus (T1DM) is still unknown; numerous studies are performed to unravel the environmental factors involved in triggering the disease. SLC11A1 is a membrane transporter that is expressed in late endosomes of antigen presenting cells involved in the immunopathogenic events leading to T1DM. Mycobacterium avium subsp. paratuberculosis (MAP) has been reported to be a possible trigger in the development of T1DM. Fifty nine T1DM patients and 79 healthy controls were genotyped for 9 polymorphisms of SLC11A1 gene, and screened for the presence of MAP by PCR. Differences in genotype frequency were evaluated for both T1DM patients and controls. We found a polymorphism in the SLC11A1 gene (274C/T) associated to type 1 diabetic patients and not to controls. The presence of MAP DNA was also significantly associated with T1DM patients and not with controls. The 274C/T SCL11A1 polymorphism was found to be associated with T1DM as well as the presence of MAP DNA in blood. Since MAP persists within macrophages and it is also processed by dendritic cells, further studies are necessary to evaluate if mutant forms of SLC11A1 alter the processing or presentation of MAP antigens triggering thereby an autoimmune response in T1DM patients.	en
heal.publisher	Public Library of Science (PLoS)	en
heal.journalName	PLoS One	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true