Effects of Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici on the nematode Caenorhabditis elegans include possible antitumor activity

dc.contributor.author	Fasseas, MK	en
dc.contributor.author	Fasseas, C	en
dc.contributor.author	Mountzouris, KC	en
dc.contributor.author	Syntichaki, P	en
dc.date.accessioned	2014-06-06T06:52:28Z
dc.date.available	2014-06-06T06:52:28Z
dc.date.issued	2013	en
dc.identifier.issn	01757598	en
dc.identifier.uri	http://dx.doi.org/10.1007/s00253-012-4357-9	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/6035
dc.subject	Antitumor	en
dc.subject	C. elegans	en
dc.subject	Immune response	en
dc.subject	Lactic acid bacteria	en
dc.subject	Probiotic	en
dc.subject.other	Anti-tumors	en
dc.subject.other	Elegans	en
dc.subject.other	Immune response	en
dc.subject.other	Lactic acid bacteria	en
dc.subject.other	Probiotics	en
dc.subject.other	Bacteria	en
dc.subject.other	Escherichia coli	en
dc.subject.other	Gene expression	en
dc.subject.other	Lactic acid	en
dc.subject.other	Laboratories	en
dc.subject.other	transcription factor DAF 16	en
dc.subject.other	bacterium	en
dc.subject.other	biotechnology	en
dc.subject.other	cancer	en
dc.subject.other	gene expression	en
dc.subject.other	growth rate	en
dc.subject.other	host-pathogen interaction	en
dc.subject.other	immune response	en
dc.subject.other	inhibition	en
dc.subject.other	mortality	en
dc.subject.other	nematode	en
dc.subject.other	parasite	en
dc.subject.other	probiotics	en
dc.subject.other	tumor	en
dc.subject.other	ultraviolet radiation	en
dc.subject.other	antineoplastic activity	en
dc.subject.other	article	en
dc.subject.other	bacterial strain	en
dc.subject.other	Caenorhabditis elegans	en
dc.subject.other	controlled study	en
dc.subject.other	Escherichia coli	en
dc.subject.other	gene expression	en
dc.subject.other	germ cell tumor	en
dc.subject.other	growth inhibition	en
dc.subject.other	Lactobacillus reuteri	en
dc.subject.other	Lactobacillus salivarius	en
dc.subject.other	lifespan	en
dc.subject.other	nonhuman	en
dc.subject.other	pathogenesis	en
dc.subject.other	Pediococcus acidilactici	en
dc.subject.other	protein localization	en
dc.subject.other	ultraviolet radiation	en
dc.subject.other	wild type	en
dc.subject.other	worm	en
dc.subject.other	Animals	en
dc.subject.other	Caenorhabditis elegans	en
dc.subject.other	Escherichia coli	en
dc.subject.other	Gene Expression Profiling	en
dc.subject.other	Germ Cells	en
dc.subject.other	Lactobacillus	en
dc.subject.other	Longevity	en
dc.subject.other	Pediococcus	en
dc.subject.other	Probiotics	en
dc.subject.other	Caenorhabditis elegans	en
dc.subject.other	Escherichia coli	en
dc.subject.other	Lactobacillus reuteri	en
dc.subject.other	Lactobacillus salivarius	en
dc.subject.other	Nematoda	en
dc.subject.other	Pediococcus acidilactici	en
dc.title	Effects of Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici on the nematode Caenorhabditis elegans include possible antitumor activity	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s00253-012-4357-9	en
heal.publicationDate	2013	en
heal.abstract	This study examined the effects of three lactic acid bacteria (LAB) strains on the nematode Caenorhabditis elegans. Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici were found to inhibit the development and growth of the worm. Compared to Escherichia coli used as the control, L. reuteri and P. acidilactici reduced the lifespan of wild-type and short-lived daf-16 worms. On the contrary, L. salivarius extended the lifespan of daf-16 worms when used live, but reduced it as UV-killed bacteria. The three LAB induced the expression of genes involved in pathogen response and inhibited the growth of tumor-like germ cells, without affecting DAF16 localization or increasing corpse cells. Our results suggest the possible use of C. elegans as a model for studying the antitumor attributes of LAB. The negative effects of these LAB strains on the nematode also indicate their potential use against parasitic nematodes. © 2012 Springer-Verlag.	en
heal.journalName	Applied Microbiology and Biotechnology	en
dc.identifier.issue	5	en
dc.identifier.volume	97	en
dc.identifier.doi	10.1007/s00253-012-4357-9	en
dc.identifier.spage	2109	en
dc.identifier.epage	2118	en