Biotoxin detection using cell-based sensors

dc.contributor.advisor	Banerjee, Pratik	en
dc.contributor.author	Kintzios, Spyridon	en
dc.contributor.author	Κίντζιος, Σπυρίδων	el
dc.contributor.author	Prabhakarpandian, Balabhaskar	en
dc.date.accessioned	2014-06-06T06:52:21Z
dc.date.available	2014-06-06T06:52:21Z
dc.date.issued	2013-11-29	en
dc.identifier.issn	20726651	en
dc.identifier.uri	http://dx.doi.org/10.3390/toxins5122366	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/5970
dc.rights	CC0 1.0 Παγκόσμια
dc.rights.uri	http://creativecommons.org/publicdomain/zero/1.0/
dc.title	Biotoxin detection using cell-based sensors	en
heal.type	other	en
heal.keyword	Βiosensor	en
heal.keyword	Toxin	en
heal.keyword	Mycotoxins	en
heal.keyword	Marine toxins	en
heal.keyword	Botulinum toxins	en
heal.keyword	Cell-based sensors	en
heal.keyword	Cell-based assay	en
heal.keyword	Cytotoxicity	en
heal.keyword	Aflatoxin M1	en
heal.keyword	Alpha hemolysin	en
heal.keyword	Botulinum toxin A	en
heal.keyword	Marine toxin	en
heal.keyword	Ecotoxicity	en
heal.keyword	Escherichia coli	en
heal.keyword	Hybridoma	en
heal.keyword	Listeria monocytogenes	en
heal.keyword	Pseudomonas putida	en
heal.keyword	Saccharomyces cerevisiae	en
heal.keyword	Salmonella typhimurium	en
heal.keyword	Staphylococcus aureus	en
heal.keyword	Vibrio cholerae	en
heal.keyword	Organophosphate	en
heal.keyword	Phosphorescence	en
heal.identifier.primary	10.3390/toxins5122366	en
heal.recordProvider	University of Memphis/School of Public Health	en
heal.recordProvider	CFD Research Corporation/Bioengineering Laboratory Core/Cellular and Biomolecular Engineering	en
heal.recordProvider	Γεωπονικό Πανεπιστήμιο Αθηνών/Τμήμα Γεωπονικής Βιοτεχνολογίας	el
heal.publicationDate	2013-11-29	en
heal.bibliographicCitation	Banerjee, Pratik. Biotoxin Detection Using Cell-Based Sensors. Toxins, vol. 5 (12), pp. 2366-2383, MDPI 2013	en
heal.abstract	Cell-based biosensors (CBBs) utilize the principles of cell-based assays (CBAs) by employing living cells for detection of different analytes from environment, food, clinical, or other sources. For toxin detection, CBBs are emerging as unique alternatives to other analytical methods. The main advantage of using CBBs for probing biotoxins and toxic agents is that CBBs respond to the toxic exposures in the manner related to actual physiologic responses of the vulnerable subjects. The results obtained from CBBs are based on the toxin-cell interactions, and therefore, reveal functional information (such as mode of action, toxic potency, bioavailability, target tissue or organ, etc.) about the toxin. CBBs incorporate both prokaryotic (bacteria) and eukaryotic (yeast, invertebrate and vertebrate) cells. To create CBB devices, living cells are directly integrated onto the biosensor platform. The sensors report the cellular responses upon exposures to toxins and the resulting cellular signals are transduced by secondary transducers generating optical or electrical signals outputs followed by appropriate read-outs. Examples of the layout and operation of cellular biosensors for detection of selected biotoxins are summarized.	en
heal.publisher	Molecular Diversity Preservation International (MDPI)	en
heal.journalName	Toxins	en
dc.identifier.doi	10.3390/toxins5122366	en