Baseline sensitivity of Monilinia laxa from Greece to fenhexamid and analysis of fenhexamid-resistant mutants

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dc.contributor.author Malandrakis, A en
dc.contributor.author Koukiasas, N en
dc.contributor.author Veloukas, T en
dc.contributor.author Karaoglanidis, G en
dc.contributor.author Markoglou, A en
dc.date.accessioned 2014-06-06T06:52:19Z
dc.date.available 2014-06-06T06:52:19Z
dc.date.issued 2013 en
dc.identifier.issn 02612194 en
dc.identifier.uri http://dx.doi.org/10.1016/j.cropro.2012.12.009 en
dc.subject Brown rot en
dc.subject Fenhexamid resistance en
dc.subject Hydroxyanilides en
dc.subject Monilia laxa en
dc.subject.other baseline conditions en
dc.subject.other disease incidence en
dc.subject.other disease resistance en
dc.subject.other fitness en
dc.subject.other fungicide en
dc.subject.other growth en
dc.subject.other laboratory method en
dc.subject.other mutagenicity en
dc.subject.other parameterization en
dc.subject.other Greece en
dc.subject.other Botryotinia fuckeliana en
dc.subject.other Candida albicans en
dc.subject.other Malus x domestica en
dc.subject.other Monilia en
dc.subject.other Monilinia en
dc.subject.other Monilinia laxa en
dc.title Baseline sensitivity of Monilinia laxa from Greece to fenhexamid and analysis of fenhexamid-resistant mutants en
heal.type journalArticle en
heal.identifier.primary 10.1016/j.cropro.2012.12.009 en
heal.publicationDate 2013 en
heal.abstract Fenhexamid is a hydroxyanilide fungicide with excellent performance against Botrytis cinerea but also effective against Monilinia spp. which cause brown rot disease in apple and stone fruit. A total of 75 Monilinia laxa field isolates were utilized to determine baseline sensitivity while a number of fenhexamid-resistant laboratory mutants were used to evaluate the resistance risk associated with the longevity of the effectiveness of fenhexamid. Fenhexamid was found to be highly effective against all field isolates. EC50 values ranged from 0.02 to 1 μg mL-1 and were distributed unimodaly around an average of 0.1 μg mL-1. M. laxa laboratory strains with moderate and high resistance levels to fenhexamid were isolated after UV mutagenesis. All fenhexamid-resistant strains showed parental sensitivity to carbendazim, iprodione, fludioxonil, pyraclostrobin, flusilazole and prochloraz. Interestingly, some of the mutant strains were also resistant to tridemorph, fenpropimorph and spiroxamine. Studies on fitness parameters of fenhexamid-resistant strains revealed a fitness cost on sporulation and pathogenicity but not on mycelial growth. These results suggest that fenhexamid should be a good alternative site-specific fungicide for the control of brown rot disease caused by M. laxa. However, appropriate anti-resistance strategies should be considered to ensure the successful commercial use of fenhexamid in the long run. © 2012 Elsevier Ltd. en
heal.journalName Crop Protection en
dc.identifier.volume 46 en
dc.identifier.doi 10.1016/j.cropro.2012.12.009 en
dc.identifier.spage 13 en
dc.identifier.epage 17 en

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