The role of selenium in cadmium toxicity: Interactions with essential and toxic elements

dc.contributor.author	Al-Waeli, A	en
dc.contributor.author	Pappas, AC	en
dc.contributor.author	Zoidis, E	en
dc.contributor.author	Georgiou, CA	en
dc.contributor.author	Fegeros, K	en
dc.contributor.author	Zervas, G	en
dc.date.accessioned	2014-06-06T06:52:10Z
dc.date.available	2014-06-06T06:52:10Z
dc.date.issued	2012	en
dc.identifier.issn	00071668	en
dc.identifier.uri	http://dx.doi.org/10.1080/00071668.2012.751523	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/5875
dc.subject.other	antioxidant	en
dc.subject.other	cadmium chloride	en
dc.subject.other	metal	en
dc.subject.other	reactive oxygen metabolite	en
dc.subject.other	selenium	en
dc.subject.other	aging	en
dc.subject.other	animal	en
dc.subject.other	animal disease	en
dc.subject.other	article	en
dc.subject.other	blood	en
dc.subject.other	chicken	en
dc.subject.other	controlled clinical trial	en
dc.subject.other	controlled study	en
dc.subject.other	diet	en
dc.subject.other	dose response	en
dc.subject.other	growth, development and aging	en
dc.subject.other	kidney	en
dc.subject.other	liver	en
dc.subject.other	mass spectrometry	en
dc.subject.other	metabolism	en
dc.subject.other	multivariate analysis	en
dc.subject.other	pectoralis major muscle	en
dc.subject.other	physiology	en
dc.subject.other	randomized controlled trial	en
dc.subject.other	statistical model	en
dc.subject.other	Aging	en
dc.subject.other	Animals	en
dc.subject.other	Antioxidants	en
dc.subject.other	Cadmium Chloride	en
dc.subject.other	Chickens	en
dc.subject.other	Diet	en
dc.subject.other	Dose-Response Relationship, Drug	en
dc.subject.other	Kidney	en
dc.subject.other	Linear Models	en
dc.subject.other	Liver	en
dc.subject.other	Mass Spectrometry	en
dc.subject.other	Metals	en
dc.subject.other	Multivariate Analysis	en
dc.subject.other	Pectoralis Muscles	en
dc.subject.other	Reactive Oxygen Species	en
dc.subject.other	Selenium	en
dc.title	The role of selenium in cadmium toxicity: Interactions with essential and toxic elements	en
heal.type	journalArticle	en
heal.identifier.primary	10.1080/00071668.2012.751523	en
heal.publicationDate	2012	en
heal.abstract	1. The study was part of a project designed to investigate if organic selenium (Se) can ameliorate the toxic effects of cadmium (Cd). The main objective of the present study was to investigate, in the chicken, the interactions between Se, Cd and the following elements: Sb, Ca, Cr, Co, Cu, Fe, Pb, Mg, Mn, Mo, Ni, V and Zn.2. A total of 300 1-d-old chickens (broilers) were randomly distributed among 4 dietary treatments with 5 replicate pens per treatment. In T1, chickens were fed on a diet with 0·3 mg/kg added Se, without added Cd. In T2, chickens were fed on a diet with 0·3 mg/kg Se and 10 mg/kg Cd. In T3, chickens were fed on a diet with 0·3 mg/kg Se and 100 mg/kg of Cd added and in T4 treatment, chickens were fed on a diet with 3 mg/kg Se and 100 mg/kg Cd added. Se was added as Se-yeast. Cd was added as cadmium chloride (CdCl2). On d 28 and 42, two chickens per replicate pen were killed for collection of whole blood, liver, kidney and breast muscle samples. Samples were analysed by ICP-MS. The data were analysed using a multivariate linear model.3. While low Cd concentrations in the diet led only to an increase of Cd concentration in the examined tissues, addition of high concentrations of Cd increased the concentration of Cd, Cu, Sb and V and decreased that of Se, Mn and Fe. Addition of high Se concentrations did not significantly reduce Cd concentration.4. Prior to model application, correlations of 78 elements were noted, while after model application 39 correlations were noted. Most notably, Cd was correlated with Ca, Co, Cu and Mg, while Se was correlated with Mn.5. The present study revealed several correlations between essential, probably essential and toxic elements illustrating the importance of the balance between pro-oxidants and antioxidants. © 2012 Copyright Taylor and Francis Group, LLC.	en
heal.journalName	British Poultry Science	en
dc.identifier.issue	6	en
dc.identifier.volume	53	en
dc.identifier.doi	10.1080/00071668.2012.751523	en
dc.identifier.spage	817	en
dc.identifier.epage	827	en