The multifaceted role of Lon proteolysis in seedling establishment and maintenance of plant organelle function: Living from protein destruction

dc.contributor.author	Rigas, S	en
dc.contributor.author	Daras, G	en
dc.contributor.author	Tsitsekian, D	en
dc.contributor.author	Hatzopoulos, P	en
dc.date.accessioned	2014-06-06T06:52:09Z
dc.date.available	2014-06-06T06:52:09Z
dc.date.issued	2012	en
dc.identifier.issn	00319317	en
dc.identifier.uri	http://dx.doi.org/10.1111/j.1399-3054.2011.01537.x	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/5871
dc.subject.other	Arabidopsis protein	en
dc.subject.other	endopeptidase La	en
dc.subject.other	Lon4 protein, Arabidopsis	en
dc.subject.other	serine proteinase	en
dc.subject.other	Arabidopsis	en
dc.subject.other	chloroplast	en
dc.subject.other	enzymology	en
dc.subject.other	genetics	en
dc.subject.other	germination	en
dc.subject.other	metabolism	en
dc.subject.other	mitochondrion	en
dc.subject.other	molecular evolution	en
dc.subject.other	oxidation reduction reaction	en
dc.subject.other	peroxisome	en
dc.subject.other	physiology	en
dc.subject.other	plant physiology	en
dc.subject.other	plant seed	en
dc.subject.other	protein degradation	en
dc.subject.other	protein transport	en
dc.subject.other	review	en
dc.subject.other	seedling	en
dc.subject.other	Arabidopsis	en
dc.subject.other	Arabidopsis Proteins	en
dc.subject.other	Chloroplasts	en
dc.subject.other	Evolution, Molecular	en
dc.subject.other	Germination	en
dc.subject.other	Mitochondria	en
dc.subject.other	Oxidation-Reduction	en
dc.subject.other	Peroxisomes	en
dc.subject.other	Plant Physiological Phenomena	en
dc.subject.other	Protease La	en
dc.subject.other	Protein Transport	en
dc.subject.other	Proteolysis	en
dc.subject.other	Seedling	en
dc.subject.other	Seeds	en
dc.subject.other	Serine Endopeptidases	en
dc.subject.other	Arabidopsis	en
dc.subject.other	Bacteria (microorganisms)	en
dc.title	The multifaceted role of Lon proteolysis in seedling establishment and maintenance of plant organelle function: Living from protein destruction	en
heal.type	other	en
heal.identifier.primary	10.1111/j.1399-3054.2011.01537.x	en
heal.publicationDate	2012	en
heal.abstract	Intracellular selective proteolysis is an important post-translational regulatory mechanism maintaining protein quality control by removing defective, damaged or even deleterious protein aggregates. The ATP-dependent Lon protease is a key component of protein quality control that is highly conserved across the kingdoms of living organisms. Major advancements have been made in bacteria and in non-plant organisms to understand the role of Lon in protection against protein oxidation, ageing and neurodegenerative diseases. This review presents the progress currently made in plants. The Lon gene family in Arabidopsis consists of four members that produce distinct protein isoforms localized in several organelles. Lon1 and Lon4 that potentially originate from a recent gene duplication event are dual-targeted to mitochondria and chloroplasts through distinct mechanisms revealing divergent evolution. Arabidopsis mutant analysis showed that mitochondria and peroxisomes biogenesis or maintenance of function is modulated by Lon1 and Lon2, respectively. Consequently, the lack of Lon selective proteolysis leading to growth retardation and impaired seedling establishment can be attributed to defects in the oil reserve mobilization pathway. The current progress in Arabidopsis research uncovers the role of Lon in the proteome homeostasis of plant organelles and stimulates biotechnology scenarios of plant tolerance against harsh abiotic conditions because of climate instability. © Physiologia Plantarum 2011.	en
heal.journalName	Physiologia Plantarum	en
dc.identifier.issue	1	en
dc.identifier.volume	145	en
dc.identifier.doi	10.1111/j.1399-3054.2011.01537.x	en
dc.identifier.spage	215	en
dc.identifier.epage	223	en