| dc.contributor.author |
Sialvera, TE |
en |
| dc.contributor.author |
Pounis, GD |
en |
| dc.contributor.author |
Koutelidakis, AE |
en |
| dc.contributor.author |
Richter, DJ |
en |
| dc.contributor.author |
Yfanti, G |
en |
| dc.contributor.author |
Kapsokefalou, M |
en |
| dc.contributor.author |
Goumas, G |
en |
| dc.contributor.author |
Chiotinis, N |
en |
| dc.contributor.author |
Diamantopoulos, E |
en |
| dc.contributor.author |
Zampelas, A |
en |
| dc.date.accessioned |
2014-06-06T06:51:59Z |
|
| dc.date.available |
2014-06-06T06:51:59Z |
|
| dc.date.issued |
2012 |
en |
| dc.identifier.issn |
09394753 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/j.numecd.2010.12.004 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/5800 |
|
| dc.subject |
Metabolic syndrome |
en |
| dc.subject |
Phytosterols |
en |
| dc.subject |
Small and dense LDL levels |
en |
| dc.subject.other |
APOA1 protein, human |
en |
| dc.subject.other |
apolipoprotein A1 |
en |
| dc.subject.other |
C reactive protein |
en |
| dc.subject.other |
fibrinogen |
en |
| dc.subject.other |
high density lipoprotein cholesterol |
en |
| dc.subject.other |
hypocholesterolemic agent |
en |
| dc.subject.other |
low density lipoprotein cholesterol |
en |
| dc.subject.other |
phytosterol |
en |
| dc.subject.other |
triacylglycerol |
en |
| dc.subject.other |
yoghurt |
en |
| dc.subject.other |
adult |
en |
| dc.subject.other |
aged |
en |
| dc.subject.other |
arterial pressure |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
blood |
en |
| dc.subject.other |
blood pressure |
en |
| dc.subject.other |
caloric intake |
en |
| dc.subject.other |
controlled clinical trial |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
coronary artery disease |
en |
| dc.subject.other |
diet |
en |
| dc.subject.other |
diet supplementation |
en |
| dc.subject.other |
drug effect |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
human |
en |
| dc.subject.other |
male |
en |
| dc.subject.other |
medical record |
en |
| dc.subject.other |
metabolic syndrome X |
en |
| dc.subject.other |
middle aged |
en |
| dc.subject.other |
pathophysiology |
en |
| dc.subject.other |
randomized controlled trial |
en |
| dc.subject.other |
risk factor |
en |
| dc.subject.other |
single blind procedure |
en |
| dc.subject.other |
Adult |
en |
| dc.subject.other |
Aged |
en |
| dc.subject.other |
Anticholesteremic Agents |
en |
| dc.subject.other |
Apolipoprotein A-I |
en |
| dc.subject.other |
Arterial Pressure |
en |
| dc.subject.other |
Blood Pressure |
en |
| dc.subject.other |
C-Reactive Protein |
en |
| dc.subject.other |
Cholesterol, HDL |
en |
| dc.subject.other |
Cholesterol, LDL |
en |
| dc.subject.other |
Coronary Artery Disease |
en |
| dc.subject.other |
Diet |
en |
| dc.subject.other |
Diet Records |
en |
| dc.subject.other |
Dietary Supplements |
en |
| dc.subject.other |
Energy Intake |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Fibrinogen |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Male |
en |
| dc.subject.other |
Metabolic Syndrome X |
en |
| dc.subject.other |
Middle Aged |
en |
| dc.subject.other |
Phytosterols |
en |
| dc.subject.other |
Risk Factors |
en |
| dc.subject.other |
Single-Blind Method |
en |
| dc.subject.other |
Triglycerides |
en |
| dc.subject.other |
Yogurt |
en |
| dc.title |
Phytosterols supplementation decreases plasma small and dense LDL levels in metabolic syndrome patients on a westernized type diet |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/j.numecd.2010.12.004 |
en |
| heal.publicationDate |
2012 |
en |
| heal.abstract |
Background and aims: Several studies have observed a hypocholesterolemic effect of plant sterols in hypercholesterolemic patients on a balanced diet. The aim of this study was to examine the effect of phytosterol supplementation on risk factors of coronary artery disease in metabolic syndrome patients on a Westernized type diet. Methods and results: In a randomized placebo-controlled design 108 patients with metabolic syndrome were assigned to consume either 2 plant sterol-enriched yogurt mini drink which provided 4 g phytosterols per day, or a yogurt beverage without phytosterols (control). The duration of the study was 2 months and the patients in both groups followed their habitual westernized type diet and recording it on food diaries. Blood samples were drawn at baseline and after 2 months of intervention. After 2 months supplementation with phytosterols, a significant reduction in total cholesterol, LDL-cholesterol, small and dense LDL (sdLDL) levels, as well as, apoB and triglycerides concentrations were observed in the intervention group (P < 0.05) compared to the control group. In addition, phytosterol supplementation lowered serum total cholesterol by 15.9%, LDL-cholesterol by 20.3% and triglyceride levels by 19.1% (P = 0.02, P < 0.001 and P < 0.001, respectively), although the patients kept their habitual westernized type diet. No differences were observed in HDL cholesterol, apoA1, glucose, C-reactive protein, fibrinogen levels and blood pressure. Conclusions: Phytosterol supplementation improves risk factors of coronary artery disease even if the diet is a westernized type. © 2011 Elsevier B.V. |
en |
| heal.journalName |
Nutrition, Metabolism and Cardiovascular Diseases |
en |
| dc.identifier.issue |
10 |
en |
| dc.identifier.volume |
22 |
en |
| dc.identifier.doi |
10.1016/j.numecd.2010.12.004 |
en |
| dc.identifier.spage |
843 |
en |
| dc.identifier.epage |
848 |
en |