| dc.contributor.author |
Tzanetou, E |
en |
| dc.contributor.author |
Liekens, S |
en |
| dc.contributor.author |
Kasiotis, KM |
en |
| dc.contributor.author |
Fokialakis, N |
en |
| dc.contributor.author |
Haroutounian, SA |
en |
| dc.date.accessioned |
2014-06-06T06:51:57Z |
|
| dc.date.available |
2014-06-06T06:51:57Z |
|
| dc.date.issued |
2012 |
en |
| dc.identifier.issn |
03656233 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1002/ardp.201200057 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/5780 |
|
| dc.subject |
Angiogenesis inhibition |
en |
| dc.subject |
Antiproliferative activity |
en |
| dc.subject |
Indazoles |
en |
| dc.subject |
Pyrazoles |
en |
| dc.subject |
Tube formation |
en |
| dc.subject.other |
3 (4 fluorophenyl) 1 (4 hydroxyphenyl) 4,5 dihydro 1h benzo[g]indazole 7 ol |
en |
| dc.subject.other |
3 (4 fluorophenyl) 7 methoxy 1 (4 methoxyphenyl) 4,5 dihydro 1h benzo[g]indazole |
en |
| dc.subject.other |
3 (4 fluorophenyl) 7 methoxy 4,5 dihydro 1h benzo[g]indazole |
en |
| dc.subject.other |
3 (4 fluorophenyl) 7 methoxy 4,5 dihydro 1h benzo[g]indazole 7 ol |
en |
| dc.subject.other |
4 [4 methyl 3 (4 nitrophenyl) 1h pyrazol 5 yl]phenol |
en |
| dc.subject.other |
4 [5 (4 methoxyphenyl) 4 methyl 1h pyrazole 3 yl]aniline |
en |
| dc.subject.other |
5 (4 methoxyphenyl) 3 (4 nitrophenyl) 1h pyrazole |
en |
| dc.subject.other |
5 (4 methoxyphenyl) 4 methyl 3 (4 nitrophenyl) 1h pyrazole |
en |
| dc.subject.other |
5 [4 (2 bromoethoxy)phenyl] 3 (4 nitrophenyl) 1h pyrazole |
en |
| dc.subject.other |
angiogenesis inhibitor |
en |
| dc.subject.other |
antineoplastic agent |
en |
| dc.subject.other |
indazole derivative |
en |
| dc.subject.other |
pyrazole derivative |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
animal cell |
en |
| dc.subject.other |
antiangiogenic activity |
en |
| dc.subject.other |
antiproliferative activity |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
cell line |
en |
| dc.subject.other |
cell strain MCF 7 |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
cytostasis |
en |
| dc.subject.other |
drug potency |
en |
| dc.subject.other |
drug screening |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
human |
en |
| dc.subject.other |
human cell |
en |
| dc.subject.other |
IC 50 |
en |
| dc.subject.other |
nonhuman |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
Acetophenones |
en |
| dc.subject.other |
Angiogenesis Inhibitors |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Breast Neoplasms |
en |
| dc.subject.other |
Cell Line, Tumor |
en |
| dc.subject.other |
Cell Proliferation |
en |
| dc.subject.other |
Endothelial Cells |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
HeLa Cells |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Indazoles |
en |
| dc.subject.other |
Inhibitory Concentration 50 |
en |
| dc.subject.other |
Mice |
en |
| dc.subject.other |
Pyrazoles |
en |
| dc.subject.other |
Tetralones |
en |
| dc.title |
Novel pyrazole and indazole derivatives: Synthesis and evaluation of their anti-proliferative and anti-angiogenic activities |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1002/ardp.201200057 |
en |
| heal.publicationDate |
2012 |
en |
| heal.abstract |
The synthesis of several new pyrazole and indazole derivatives from acetophenone and tetralone substrates is reported. The bioactivities of the new compounds were evaluated through in vitro assays for endothelial cell proliferation and tube formation. Results herein indicate that the easily prepared compounds containing the indazole structural framework exhibit potent cytostatic properties against all cell lines tested, with compounds 13 and 14 being the most active displaying IC50 values of 1.5 ± 0.4 μM and 5.6 ± 2.5 μM, respectively, against MCF-7 cells. In addition, the indazole derivative 16 was assessed as a competent inhibitor of endothelial tube formation at 30 μM. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
en |
| heal.journalName |
Archiv der Pharmazie |
en |
| dc.identifier.issue |
10 |
en |
| dc.identifier.volume |
345 |
en |
| dc.identifier.doi |
10.1002/ardp.201200057 |
en |
| dc.identifier.spage |
804 |
en |
| dc.identifier.epage |
811 |
en |