| dc.contributor.author |
Theodorou, G |
en |
| dc.contributor.author |
Lampidonis, AD |
en |
| dc.contributor.author |
Laliotis, GP |
en |
| dc.contributor.author |
Bizelis, I |
en |
| dc.contributor.author |
Politis, I |
en |
| dc.date.accessioned |
2014-06-06T06:51:48Z |
|
| dc.date.available |
2014-06-06T06:51:48Z |
|
| dc.date.issued |
2012 |
en |
| dc.identifier.issn |
09312439 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1111/j.1439-0396.2011.01154.x |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/5707 |
|
| dc.subject |
Adipose tissue |
en |
| dc.subject |
Gene expression |
en |
| dc.subject |
Hormone-sensitive lipase |
en |
| dc.subject |
Lipolysis |
en |
| dc.subject.other |
plasminogen activator |
en |
| dc.subject.other |
adipose tissue |
en |
| dc.subject.other |
animal |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
classification |
en |
| dc.subject.other |
dairying |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
gene expression regulation |
en |
| dc.subject.other |
genetics |
en |
| dc.subject.other |
lactation |
en |
| dc.subject.other |
metabolism |
en |
| dc.subject.other |
physiology |
en |
| dc.subject.other |
sheep |
en |
| dc.subject.other |
weaning |
en |
| dc.subject.other |
Adipose Tissue |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Dairying |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Gene Expression Regulation |
en |
| dc.subject.other |
Lactation |
en |
| dc.subject.other |
Plasminogen Activators |
en |
| dc.subject.other |
Sheep |
en |
| dc.subject.other |
Weaning |
en |
| dc.subject.other |
Ovis |
en |
| dc.subject.other |
Ovis aries |
en |
| dc.title |
Expression of plasminogen activator-related genes in the adipose tissue of lactating dairy sheep in the early post-weaning period |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1111/j.1439-0396.2011.01154.x |
en |
| heal.publicationDate |
2012 |
en |
| heal.abstract |
There is growing evidence that plasminogen activator inhibitor type 1 (PAI-1) is expressed in adipose tissue and its expression is implicated in inflammation that accompanies obesity-associated diseases. The physiological role of other genes implicated in the plasminogen-activating cascade such as urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitor type 2 (PAI-2) in ovine adipose tissue remains unknown. The objective of this study was to examine the changes in the expression of four plasminogen activator (PA)-related genes during the early post-weaning period in dairy ewes. A total of 21 subcutaneous adipose tissue samples were obtained from seven lactating dairy ewes of the Chios breed at weeks1, 2 and 4 after weaning. Results indicated that expression of all PA-related genes was detected in most of the samples examined. Greatest expression of u-PAR corresponded to highest (week1), while greatest expression of PAI-2 corresponded to lowest (week4) rate of lipolysis, as indicated by the expression of hormone-sensitive lipase, in the ovine adipose tissue. There were no significant differences in the expression of the other two PA-related genes (u-PA, PAI-1) throughout the experimental period. Plasminogen activator-related genes are not expressed in a coordinated manner in the adipose tissue of lactating dairy sheep in the early post-weaning period. In conclusion, adipose tissue mobilization is correlated with highest expression of u-PAR and lowest expression of PAI-2. © 2011 Blackwell Verlag GmbH. |
en |
| heal.journalName |
Journal of Animal Physiology and Animal Nutrition |
en |
| dc.identifier.issue |
3 |
en |
| dc.identifier.volume |
96 |
en |
| dc.identifier.doi |
10.1111/j.1439-0396.2011.01154.x |
en |
| dc.identifier.spage |
403 |
en |
| dc.identifier.epage |
407 |
en |