| dc.contributor.author |
Spanou, CI |
en |
| dc.contributor.author |
Veskoukis, AS |
en |
| dc.contributor.author |
Stagos, D |
en |
| dc.contributor.author |
Liadaki, K |
en |
| dc.contributor.author |
Aligiannis, N |
en |
| dc.contributor.author |
Angelis, A |
en |
| dc.contributor.author |
Skaltsounis, A-L |
en |
| dc.contributor.author |
Anastasiadi, M |
en |
| dc.contributor.author |
Haroutounian, SA |
en |
| dc.contributor.author |
Kouretas, D |
en |
| dc.date.accessioned |
2014-06-06T06:51:45Z |
|
| dc.date.available |
2014-06-06T06:51:45Z |
|
| dc.date.issued |
2012 |
en |
| dc.identifier.issn |
11387548 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1007/s13105-011-0117-z |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/5676 |
|
| dc.subject |
Antioxidant enzymes |
en |
| dc.subject |
Legumes |
en |
| dc.subject |
Plant extracts |
en |
| dc.subject |
Xanthine oxidase |
en |
| dc.subject.other |
allopurinol |
en |
| dc.subject.other |
antioxidant |
en |
| dc.subject.other |
catalase |
en |
| dc.subject.other |
Lathyrus clymenum extract |
en |
| dc.subject.other |
Lathyrus laxiflorus extract |
en |
| dc.subject.other |
Lathyrus sativus extract |
en |
| dc.subject.other |
Lens culinaris extract |
en |
| dc.subject.other |
Lotus edulis extract |
en |
| dc.subject.other |
Lotus longisiliquosus extract |
en |
| dc.subject.other |
Lupinus albus extract |
en |
| dc.subject.other |
phaseolus vulgaris extract |
en |
| dc.subject.other |
plant extract |
en |
| dc.subject.other |
sodium azide |
en |
| dc.subject.other |
superoxide dismutase |
en |
| dc.subject.other |
Tetragonolobus purpureus extract |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
Vicia tenuifolia extract |
en |
| dc.subject.other |
xanthine oxidase |
en |
| dc.subject.other |
xanthine oxidase inhibitor |
en |
| dc.subject.other |
adult |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
chemical composition |
en |
| dc.subject.other |
concentration response |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
drug determination |
en |
| dc.subject.other |
drug isolation |
en |
| dc.subject.other |
enzyme activity |
en |
| dc.subject.other |
enzyme induction |
en |
| dc.subject.other |
enzyme inhibition |
en |
| dc.subject.other |
Greece |
en |
| dc.subject.other |
human |
en |
| dc.subject.other |
human cell |
en |
| dc.subject.other |
IC 50 |
en |
| dc.subject.other |
Lathyrus clymenum |
en |
| dc.subject.other |
Lathyrus laxiflorus |
en |
| dc.subject.other |
Lathyrus sativus |
en |
| dc.subject.other |
legume |
en |
| dc.subject.other |
lentil |
en |
| dc.subject.other |
Lotus edulis |
en |
| dc.subject.other |
Lotus longisiliquosus |
en |
| dc.subject.other |
lupinus albus |
en |
| dc.subject.other |
male |
en |
| dc.subject.other |
medicinal plant |
en |
| dc.subject.other |
normal human |
en |
| dc.subject.other |
Phaseolus vulgaris |
en |
| dc.subject.other |
plant leaf |
en |
| dc.subject.other |
plant seed |
en |
| dc.subject.other |
Tetragonolobus purpureus |
en |
| dc.subject.other |
Vicia faba |
en |
| dc.subject.other |
Vicia tenuifolia |
en |
| dc.subject.other |
Adult |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Catalase |
en |
| dc.subject.other |
Cattle |
en |
| dc.subject.other |
Cell Extracts |
en |
| dc.subject.other |
Erythrocytes |
en |
| dc.subject.other |
Fabaceae |
en |
| dc.subject.other |
Greece |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Male |
en |
| dc.subject.other |
Milk |
en |
| dc.subject.other |
Plant Components, Aerial |
en |
| dc.subject.other |
Plant Extracts |
en |
| dc.subject.other |
Polyphenols |
en |
| dc.subject.other |
Superoxide Dismutase |
en |
| dc.subject.other |
Xanthine Oxidase |
en |
| dc.subject.other |
Rattus |
en |
| dc.title |
Effects of Greek legume plant extracts on xanthine oxidase, catalase and superoxide dismutase activities |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1007/s13105-011-0117-z |
en |
| heal.publicationDate |
2012 |
en |
| heal.abstract |
Legumes are considered to have beneficial health implications, which have been attributed to their phytochemical content. Polyphenols are considered the most important phytochemical compounds extensively studied for their antioxidant properties. The aim of the present study was to examine the effects of potent antioxidant legume plant extracts on xanthine oxidase (XO), catalase (CAT) and superoxide dismutase (SOD) activities. XO exerts a dual role, as it is the major contributor of free radicals during exercise while it generates uric acid, the most potent antioxidant molecule in plasma. CAT and SOD are two of the main enzymes of the antioxidant defence of tissues. We demonstrate that the majority of the extracts inhibited XO activity, but they had no effect on CAT inhibition and SOD induction when used at low concentrations. These results imply that the tested extracts may be considered as possible source of novel XO inhibitors. However, we have shown that allopurinol administration, a known XO inhibitor, before exercise reduces performance and induces oxidative stress in rats. Considering the fact that the extracts examined had an inhibitory effect on XO activity, possibly posing a restriction in their characterization as antioxidants, phytochemical antioxidant administration before exercise should probably be reconsidered. © 2011 University of Navarra. |
en |
| heal.journalName |
Journal of Physiology and Biochemistry |
en |
| dc.identifier.issue |
1 |
en |
| dc.identifier.volume |
68 |
en |
| dc.identifier.doi |
10.1007/s13105-011-0117-z |
en |
| dc.identifier.spage |
37 |
en |
| dc.identifier.epage |
45 |
en |