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Continuous-flow ferrohydrodynamic sorting of particles and cells in microfluidic devices

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dc.contributor.author Zhu, T en
dc.contributor.author Cheng, R en
dc.contributor.author Lee, SA en
dc.contributor.author Rajaraman, E en
dc.contributor.author Eiteman, MA en
dc.contributor.author Querec, TD en
dc.contributor.author Unger, ER en
dc.contributor.author Mao, L en
dc.date.accessioned 2014-06-06T06:51:42Z
dc.date.available 2014-06-06T06:51:42Z
dc.date.issued 2012 en
dc.identifier.issn 16134982 en
dc.identifier.uri http://dx.doi.org/10.1007/s10404-012-1004-9 en
dc.identifier.uri http://62.217.125.90/xmlui/handle/123456789/5641
dc.subject Cell sorting en
dc.subject Continuous-flow en
dc.subject Ferrofluid en
dc.subject Ferrohydrodynamics en
dc.subject Microfluidics en
dc.subject.other Cell sorting en
dc.subject.other Continuous-flow en
dc.subject.other Ferrofluid en
dc.subject.other Ferrohydrodynamics en
dc.subject.other Label free en
dc.subject.other Live cell en
dc.subject.other Magnetic buoyancy force en
dc.subject.other Magnetic nanoparticles en
dc.subject.other Micro-fluidic devices en
dc.subject.other Micro-particles en
dc.subject.other Sorting device en
dc.subject.other Spatial separation en
dc.subject.other Under external magnetic field en
dc.subject.other Cells en
dc.subject.other Cytology en
dc.subject.other Escherichia coli en
dc.subject.other Laminar flow en
dc.subject.other Magnetic fluids en
dc.subject.other Microfluidics en
dc.subject.other Polystyrenes en
dc.subject.other Yeast en
dc.subject.other Screening en
dc.title Continuous-flow ferrohydrodynamic sorting of particles and cells in microfluidic devices en
heal.type journalArticle en
heal.identifier.primary 10.1007/s10404-012-1004-9 en
heal.publicationDate 2012 en
heal.abstract A new sorting scheme based on ferrofluid hydrodynamics (ferrohydrodynamics) was used to separate mixtures of particles and live cells simultaneously. Two species of cells, including Escherichia coli and Saccharomyces cerevisiae, as well as fluorescent polystyrene microparticles were studied for their sorting throughput and efficiency. Ferrofluids are stable magnetic nanoparticles suspensions. Under external magnetic field gradients, magnetic buoyancy forces exerted on particles and cells lead to size-dependent deflections from their laminar flow paths and result in spatial separation. We report the design, modeling, fabrication and characterization of the sorting device. This scheme is simple, low-cost and label-free compared to other existing techniques. © Springer-Verlag 2012. en
heal.journalName Microfluidics and Nanofluidics en
dc.identifier.issue 4 en
dc.identifier.volume 13 en
dc.identifier.doi 10.1007/s10404-012-1004-9 en
dc.identifier.spage 645 en
dc.identifier.epage 654 en


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