Topiramate promotes neurological recovery in a new model of traumatic brain injury in rats

dc.contributor.author	Kouzounias, K	en
dc.contributor.author	Kimiskidis, VK	en
dc.contributor.author	Siozos, T	en
dc.contributor.author	Violaris, K	en
dc.contributor.author	Kostomitsopoulos, N	en
dc.contributor.author	Karayannakos, PE	en
dc.contributor.author	Sotirakoglou, K	en
dc.contributor.author	Nanassis, K	en
dc.date.accessioned	2014-06-06T06:51:30Z
dc.date.available	2014-06-06T06:51:30Z
dc.date.issued	2011	en
dc.identifier.issn	03064522	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.neuroscience.2011.03.069	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/5543
dc.subject	Neuroprotection	en
dc.subject	Topiramate	en
dc.subject	Traumatic brain injury	en
dc.subject.other	placebo	en
dc.subject.other	topiramate	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	brain water	en
dc.subject.other	controlled study	en
dc.subject.other	dose response	en
dc.subject.other	drug activity	en
dc.subject.other	drug efficacy	en
dc.subject.other	drug megadose	en
dc.subject.other	hemisphere	en
dc.subject.other	histopathology	en
dc.subject.other	male	en
dc.subject.other	neuroprotection	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	rat	en
dc.subject.other	traumatic brain injury	en
dc.subject.other	Animals	en
dc.subject.other	Brain Edema	en
dc.subject.other	Brain Injuries	en
dc.subject.other	Disease Models, Animal	en
dc.subject.other	Fructose	en
dc.subject.other	Functional Laterality	en
dc.subject.other	Male	en
dc.subject.other	Multivariate Analysis	en
dc.subject.other	Nervous System Diseases	en
dc.subject.other	Neurologic Examination	en
dc.subject.other	Neuroprotective Agents	en
dc.subject.other	Rats	en
dc.subject.other	Rats, Wistar	en
dc.subject.other	Recovery of Function	en
dc.subject.other	Time Factors	en
dc.title	Topiramate promotes neurological recovery in a new model of traumatic brain injury in rats	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.neuroscience.2011.03.069	en
heal.publicationDate	2011	en
heal.abstract	The aim of this study is to investigate the neuroprotective effects of the anticonvulsant topiramate in a new model of traumatic brain injury in rats. A new model of traumatic brain injury, based on the weight-drop technique, was developed for the purpose of this study. Seventy-five male Wistar rats weighing 320-470 g were studied. All rats were anesthetized, subsequently submitted to a round craniectomy in the left parietal region and a weight of 50 g was used for the production of a cortical contusion. In study I, 44 rats were randomized in three groups to receive either topiramate 40 mg/kg (n=13), topiramate 60 mg/kg (n=14), or water for injection (n=17) i.p. 30 min after the injury and every 12 h thereafter for 3 days. The rats were tested clinically 24 h, 72 h, 10 days and 20 days after the injury. On day 21 the animals were sacrificed and the brains were removed and prepared for histopathological analysis. In study II, 19 rats were randomized to receive either topiramate 60 mg/kg (n=10) or water for injection (n=9) i.p. 30 min after the injury and every 12 h (four doses in total). 48 h after the injury the animals were sacrificed and the brains were rapidly removed and analyzed for water content with the dry-wet weight technique. The animals that received topiramate performed significantly better in neurological tests compared to the animals that received vehicle ten (P<0.05) and 20 (P<0.001) days after the injury. There was no difference between the high and the low dose of the drug. Topiramate had no effect on the anatomic volume of the lesion. The animals that received topiramate had a tendency to present with less cerebral edema formation, but the difference was not statistically significant (P>0.05). These findings suggest that topiramate promotes neurological recovery in rats after traumatic brain injury without affecting the final size of the traumatic lesion and that it might play a role in the reduction of post-traumatic cerebral edema. © 2011 IBRO.	en
heal.journalName	Neuroscience	en
dc.identifier.volume	183	en
dc.identifier.doi	10.1016/j.neuroscience.2011.03.069	en
dc.identifier.spage	171	en
dc.identifier.epage	177	en