| dc.contributor.author |
Aliferis, KA |
en |
| dc.contributor.author |
Chrysayi-Tokousbalides, M |
en |
| dc.date.accessioned |
2014-06-06T06:51:22Z |
|
| dc.date.available |
2014-06-06T06:51:22Z |
|
| dc.date.issued |
2011 |
en |
| dc.identifier.issn |
15733882 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1007/s11306-010-0231-x |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/5478 |
|
| dc.subject |
Bioactive compounds |
en |
| dc.subject |
Crop protection |
en |
| dc.subject |
Natural products |
en |
| dc.subject |
Pesticides |
en |
| dc.subject.other |
antibiotic agent |
en |
| dc.subject.other |
antifungal agent |
en |
| dc.subject.other |
herbicide |
en |
| dc.subject.other |
insecticide |
en |
| dc.subject.other |
pesticide |
en |
| dc.subject.other |
capillary electrophoresis |
en |
| dc.subject.other |
chemical analysis |
en |
| dc.subject.other |
cluster analysis |
en |
| dc.subject.other |
computer program |
en |
| dc.subject.other |
data mining |
en |
| dc.subject.other |
discriminant analysis |
en |
| dc.subject.other |
ecotoxicology |
en |
| dc.subject.other |
gas chromatography |
en |
| dc.subject.other |
high performance liquid chromatography |
en |
| dc.subject.other |
high throughput screening |
en |
| dc.subject.other |
information processing |
en |
| dc.subject.other |
mass spectrometry |
en |
| dc.subject.other |
metabolomics |
en |
| dc.subject.other |
nonhuman |
en |
| dc.subject.other |
nuclear magnetic resonance spectroscopy |
en |
| dc.subject.other |
partial least squares regression |
en |
| dc.subject.other |
principal component analysis |
en |
| dc.subject.other |
reference database |
en |
| dc.subject.other |
review |
en |
| dc.subject.other |
risk assessment |
en |
| dc.subject.other |
time of flight mass spectrometry |
en |
| dc.subject.other |
toxicity testing |
en |
| dc.subject.other |
transgenic plant |
en |
| dc.subject.other |
ultra performance liquid chromatography |
en |
| dc.title |
Metabolomics in pesticide research and development: Review and future perspectives |
en |
| heal.type |
other |
en |
| heal.identifier.primary |
10.1007/s11306-010-0231-x |
en |
| heal.publicationDate |
2011 |
en |
| heal.abstract |
The emerge of metabolomics within functional genomics has provided a new dimension in the study of biological systems. In regards to the study of agroecosystems, metabolomics enables monitoring of metabolic changes in association with biotic or abiotic agents such as agrochemicals. Focusing on crop protection chemicals, a great effort has been given towards the development of crop protection agents safer for consumers and the environment and more efficient than the existing ones. Within this framework, metabolomics has so far been a valuable tool for high-throughput screening of bioactive substances in order to discover those with high selectivity, unique modes-of-action, and acceptable eco-toxicological/toxicological profiles. Here, applications of metabolomics in the investigation of the modes-of-action and ecotoxicological-toxicological risk assessment of bioactive compounds, mining of biological systems for the discovery of bioactive metabolites, and the risk assessment of genetic modified crops are discussed. © 2010 Springer Science+Business Media, LLC. |
en |
| heal.journalName |
Metabolomics |
en |
| dc.identifier.issue |
1 |
en |
| dc.identifier.volume |
7 |
en |
| dc.identifier.doi |
10.1007/s11306-010-0231-x |
en |
| dc.identifier.spage |
35 |
en |
| dc.identifier.epage |
53 |
en |