Structure and antioxidant catalytic function of plant glutathione transferases

dc.contributor.author	Chronopoulou, E	en
dc.contributor.author	Axarli, I	en
dc.contributor.author	Nianiou-Obeidat, I	en
dc.contributor.author	Madesis, P	en
dc.contributor.author	Tsaftaris, A	en
dc.contributor.author	Labrou, NE	en
dc.date.accessioned	2014-06-06T06:51:02Z
dc.date.available	2014-06-06T06:51:02Z
dc.date.issued	2011	en
dc.identifier.issn	18723136	en
dc.identifier.uri	http://dx.doi.org/10.2174/187231311793564306	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/5286
dc.subject	Abiotic stress	en
dc.subject	Biotic stress	en
dc.subject	Glutathione transferase	en
dc.subject	Herbicide detoxification	en
dc.subject.other	glutathione transferase	en
dc.subject.other	ligand	en
dc.subject.other	vegetable protein	en
dc.subject.other	antioxidant activity	en
dc.subject.other	article	en
dc.subject.other	binding site	en
dc.subject.other	catalysis	en
dc.subject.other	electrophilicity	en
dc.subject.other	enzyme structure	en
dc.subject.other	ligand binding	en
dc.subject.other	nonhuman	en
dc.subject.other	nucleotide sequence	en
dc.subject.other	plant	en
dc.subject.other	priority journal	en
dc.subject.other	protein function	en
dc.subject.other	protein interaction	en
dc.subject.other	structure analysis	en
dc.title	Structure and antioxidant catalytic function of plant glutathione transferases	en
heal.type	journalArticle	en
heal.identifier.primary	10.2174/187231311793564306	en
heal.publicationDate	2011	en
heal.abstract	Plant cytosolic glutathione transferases (GSTs) are an ancient enzyme superfamily with multiple and diverse functions which are important in counteracting biotic and abiotic stresses. GSTs play an important role in catalyzing the conjugation of xenobiotics and endogenous electrophilic compounds with glutathione (GSH), such as pesticides, chemical carcinogens, environmental pollutants, which leads to their detoxification. GSTs not only catalyze detoxification reactions but they are also involved in GSH-dependent isomerization reactions, in GSH-dependent reduction of organic hydroperoxides formed during oxidative stress, biosynthesis of sulfur-containing secondary metabolites, and exhibit thioltransferase and dehydroascorbate reductase activity. This review focuses on plant GSTs, and attempts to give an overview of the new insights into the catalytic function and structural biology of these enzymes. © 2011 Bentham Science Publishers Ltd.	en
heal.journalName	Current Chemical Biology	en
dc.identifier.issue	1	en
dc.identifier.volume	5	en
dc.identifier.doi	10.2174/187231311793564306	en
dc.identifier.spage	64	en
dc.identifier.epage	74	en