Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activity

dc.contributor.author	Christodoulou, MS	en
dc.contributor.author	Liekens, S	en
dc.contributor.author	Kasiotis, KM	en
dc.contributor.author	Haroutounian, SA	en
dc.date.accessioned	2014-06-06T06:50:36Z
dc.date.available	2014-06-06T06:50:36Z
dc.date.issued	2010	en
dc.identifier.issn	09680896	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.bmc.2010.04.076	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/5082
dc.subject	Angiogenesis	en
dc.subject	CAM assay	en
dc.subject	Endothelial cell proliferation and migration	en
dc.subject	Inhibition of tumor growth	en
dc.subject	Pyrazole	en
dc.subject	Pyrazolo[4,3-c]quinoline	en
dc.subject.other	1 (4' hydroxyphenyl) 3 (3'' hydroxyphenyl) 1h pyrazole 4 carboxaldehye	en
dc.subject.other	1 (4' hydroxyphenyl) 3 (3'',4'' dihydroxyphenyl) 1h pyrazole 4 carboxaldehyde	en
dc.subject.other	1 (4' hydroxyphenyl) 3 (4'' hydroxyphenyl) 1h pyrazole 4 carboxaldehyde	en
dc.subject.other	1 (4' hydroxyphenyl) 3 phenyl 1h pyrazole 4 carboxaldehyde	en
dc.subject.other	4 [4 (1,4 benzodioxan 6 yl) 5 methyl 1h pyrazol 3 yl] 6 ethylresorcinol	en
dc.subject.other	5 hydroxy 2 (4' hydroxyphenyl) 2h pyrazolo[4,3 c]quinolin 4(5h) one	en
dc.subject.other	5,7 dihydroxy 2 (4' hydroxyphenyl) 2h pyrazolo[4,3 c]quinolin 4(5h) one	en
dc.subject.other	5,8 dihydroxy 2 (4' hydroxyphenyl) 2h pyrazolo[4,3 c]quinolin 4 one	en
dc.subject.other	angiogenesis inhibitor	en
dc.subject.other	pyrazole derivative	en
dc.subject.other	semaxanib	en
dc.subject.other	unclassified drug	en
dc.subject.other	xrp 44x	en
dc.subject.other	animal cell	en
dc.subject.other	animal experiment	en
dc.subject.other	antiangiogenic activity	en
dc.subject.other	antineoplastic activity	en
dc.subject.other	article	en
dc.subject.other	bioassay	en
dc.subject.other	breast carcinoma	en
dc.subject.other	cancer inhibition	en
dc.subject.other	carcinoma cell	en
dc.subject.other	cell migration	en
dc.subject.other	cell proliferation	en
dc.subject.other	chicken	en
dc.subject.other	chorioallantois	en
dc.subject.other	controlled study	en
dc.subject.other	drug potency	en
dc.subject.other	drug screening	en
dc.subject.other	drug synthesis	en
dc.subject.other	endothelium cell	en
dc.subject.other	HeLa cell	en
dc.subject.other	human	en
dc.subject.other	human cell	en
dc.subject.other	in vitro study	en
dc.subject.other	mouse	en
dc.subject.other	nonhuman	en
dc.subject.other	Angiogenesis Inhibitors	en
dc.subject.other	Animals	en
dc.subject.other	Cell Line, Tumor	en
dc.subject.other	Cell Movement	en
dc.subject.other	Chickens	en
dc.subject.other	Chorioallantoic Membrane	en
dc.subject.other	Cytostatic Agents	en
dc.subject.other	Endothelial Cells	en
dc.subject.other	Humans	en
dc.subject.other	Mice	en
dc.subject.other	Pyrazoles	en
dc.subject.other	Quinolines	en
dc.title	Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activity	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.bmc.2010.04.076	en
heal.publicationDate	2010	en
heal.abstract	The synthesis of a series of novel trisubstituted pyrazole derivatives and their PIFA-mediated conversion to molecules bearing the fused pyrazolo[4,3-c]quinoline ring system is reported. The anti-angiogenic activity of these compounds was evaluated by using in vitro assays for endothelial cell proliferation and migration, and in the chicken chorioallantoic membrane (CAM) assay. Compounds containing the fused pyrazolo[4,3-c]quinoline motifs emerged as potent anti-angiogenic compounds, which also had the ability to inhibit the growth of human breast (MCF-7) and cervical (Hela) carcinoma cells in vitro. © 2010 Elsevier Ltd. All rights reserved.	en
heal.journalName	Bioorganic and Medicinal Chemistry	en
dc.identifier.issue	12	en
dc.identifier.volume	18	en
dc.identifier.doi	10.1016/j.bmc.2010.04.076	en
dc.identifier.spage	4338	en
dc.identifier.epage	4350	en