A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes

dc.contributor.author	Papakonstantinou, E	en
dc.contributor.author	Triantafillidou, D	en
dc.contributor.author	Panagiotakos, DB	en
dc.contributor.author	Koutsovasilis, A	en
dc.contributor.author	Saliaris, M	en
dc.contributor.author	Manolis, A	en
dc.contributor.author	Melidonis, A	en
dc.contributor.author	Zampelas, A	en
dc.date.accessioned	2014-06-06T06:49:58Z
dc.date.available	2014-06-06T06:49:58Z
dc.date.issued	2010	en
dc.identifier.issn	09543007	en
dc.identifier.uri	http://dx.doi.org/10.1038/ejcn.2010.29	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4930
dc.subject	Coronary heart disease	en
dc.subject	Diabetes	en
dc.subject	Diet	en
dc.subject	Obesity	en
dc.subject	Protein	en
dc.subject.other	carbohydrate	en
dc.subject.other	cholesterol	en
dc.subject.other	fat	en
dc.subject.other	glucose	en
dc.subject.other	hemoglobin A1c	en
dc.subject.other	insulin	en
dc.subject.other	lipid	en
dc.subject.other	low density lipoprotein cholesterol	en
dc.subject.other	protein	en
dc.subject.other	triacylglycerol	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	body mass	en
dc.subject.other	caloric restriction	en
dc.subject.other	cardiovascular risk	en
dc.subject.other	cholesterol blood level	en
dc.subject.other	clinical article	en
dc.subject.other	controlled study	en
dc.subject.other	diastolic blood pressure	en
dc.subject.other	diet restriction	en
dc.subject.other	female	en
dc.subject.other	glucose blood level	en
dc.subject.other	glycemic control	en
dc.subject.other	human	en
dc.subject.other	insulin blood level	en
dc.subject.other	insulin sensitivity	en
dc.subject.other	low fat diet	en
dc.subject.other	male	en
dc.subject.other	metabolic regulation	en
dc.subject.other	non insulin dependent diabetes mellitus	en
dc.subject.other	obesity	en
dc.subject.other	protein diet	en
dc.subject.other	systolic blood pressure	en
dc.subject.other	weight reduction	en
dc.subject.other	Adipose Tissue	en
dc.subject.other	Adult	en
dc.subject.other	Blood Pressure	en
dc.subject.other	Caloric Restriction	en
dc.subject.other	Cholesterol	en
dc.subject.other	Cholesterol, LDL	en
dc.subject.other	Cross-Over Studies	en
dc.subject.other	Diabetes Mellitus, Type 2	en
dc.subject.other	Diet, Fat-Restricted	en
dc.subject.other	Diet, Protein-Restricted	en
dc.subject.other	Dietary Fats	en
dc.subject.other	Dietary Proteins	en
dc.subject.other	Female	en
dc.subject.other	Glucose Intolerance	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.subject.other	Obesity	en
dc.subject.other	Single-Blind Method	en
dc.subject.other	Triglycerides	en
dc.subject.other	Weight Loss	en
dc.title	A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes	en
heal.type	journalArticle	en
heal.identifier.primary	10.1038/ejcn.2010.29	en
heal.publicationDate	2010	en
heal.abstract	Background/Objectives: There is controversy over dietary protein's effects on cardiovascular disease risk factors in diabetic subjects. It is unclear whether observed effects are due to increased protein or reduced carbohydrate content of the consumed diets. The aim of this study was to compare the effects of two diets differing in protein to fat ratios on cardiovascular disease risk factors. Subjects/Methods: A total of 17 obese (body mass index (BMI) ranging from 31 to 45 kg/m2) volunteers with type 2 diabetes (DM2), aged 46±3 years, consumed two diets, each for 4 weeks, with 3 weeks of washout period in a random, blind, crossover design. The diets were: (1) a high-protein low-fat diet (HP-LF, with 30% protein, 50% carbohydrates and 20% fat) and (2) a low-protein high-fat diet (LP-HF, with 15% protein, 50% carbohydrates and 35% fat). Their effects on fasting glycemic control, lipid levels and blood pressure, and on postprandial glucose and insulin responses after a standard test meal at the beginning and end of each dietary intervention were analyzed. Results: Both diets were equally effective in promoting weight loss and fat loss and in improving fasting glycemic control, total cholesterol and low-density lipoprotein (LDL) cholesterol, but the HP-LF diet decreased to a greater extent triglyceride (TG) levels (P=0.04) when compared with the LP-HF diet. HP-LF diet improved significantly both systolic and diastolic blood pressure when compared with the LP-HF diet (P<0.001 and P<0.001, respectively). No differences were observed in postprandial glucose and insulin responses. Conclusions: A protein to fat ratio of 1.5 in diets significantly improves blood pressure and TG concentrations in obese individuals with DM2. © 2010 Macmillan Publishers Limited All rights reserved.	en
heal.journalName	European Journal of Clinical Nutrition	en
dc.identifier.issue	6	en
dc.identifier.volume	64	en
dc.identifier.doi	10.1038/ejcn.2010.29	en
dc.identifier.spage	595	en
dc.identifier.epage	602	en