Antioxidant saffron constituents bind DNA and tRNA

dc.contributor.author	Kanakis, CD	en
dc.contributor.author	Tarantilis, PA	en
dc.contributor.author	Polissiou, MG	en
dc.contributor.author	Tajmir-Riahi, HA	en
dc.date.accessioned	2014-06-06T06:49:42Z
dc.date.available	2014-06-06T06:49:42Z
dc.date.issued	2010	en
dc.identifier.issn	05677572	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4736
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-77950988015&partnerID=40&md5=52bfc5029afcd9e4e06e1eabd4bc6958	en
dc.subject	Binding constant	en
dc.subject	Binding sites	en
dc.subject	Conformation	en
dc.subject	Crocus sativus L.	en
dc.subject	FT-IR	en
dc.subject	UV-Visible	en
dc.subject.other	Crocus	en
dc.subject.other	Crocus sativus	en
dc.title	Antioxidant saffron constituents bind DNA and tRNA	en
heal.type	journalArticle	en
heal.publicationDate	2010	en
heal.abstract	Crocetin (CRT) and dimethylcrocetin (DMCRT) are derived from saffron's carotenoids while safranal is the main component of its essential oil. The antioxidant activity of these compounds was tested by the DPPH antioxidant activity assay. Also the interactions of CRT, DMCRT and safranal with calf-thymus DNA and transfer RNA in aqueous solution at physiological conditions are reported. The structural analysis showed external binding to the major or minor groove and some degree of intercalation of saffron compounds to DNA and RNA. A partial B- to A-DNA transition occurs at high ligand concentration while tRNA remains in the A-family.	en
heal.journalName	Acta Horticulturae	en
dc.identifier.volume	850	en
dc.identifier.spage	217	en
dc.identifier.epage	222	en