Synthesis of novel benzoquinones with anti-inflammatory activity

dc.contributor.author	Sagnou, M	en
dc.contributor.author	Strongilos, A	en
dc.contributor.author	Hadjipavlou-Litina, D	en
dc.contributor.author	Couladouros, EA	en
dc.date.accessioned	2014-06-06T06:49:36Z
dc.date.available	2014-06-06T06:49:36Z
dc.date.issued	2009	en
dc.identifier.issn	15701808	en
dc.identifier.uri	http://dx.doi.org/10.2174/157018009787847792	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4675
dc.subject	Benzoquinones	en
dc.subject	Inflammation	en
dc.subject	LOX	en
dc.subject	Psoriasis	en
dc.subject	Radical scavengers	en
dc.subject	Shikonin	en
dc.subject.other	benzoquinone derivative	en
dc.subject.other	hydroxyl radical	en
dc.subject.other	indometacin	en
dc.subject.other	lipoxygenase	en
dc.subject.other	nordihydroguaiaretic acid	en
dc.subject.other	shikonin	en
dc.subject.other	trolox C	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	antiinflammatory activity	en
dc.subject.other	article	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	enzyme inhibition	en
dc.subject.other	nonhuman	en
dc.subject.other	paw edema	en
dc.subject.other	priority journal	en
dc.subject.other	rat	en
dc.subject.other	structure activity relation	en
dc.title	Synthesis of novel benzoquinones with anti-inflammatory activity	en
heal.type	journalArticle	en
heal.identifier.primary	10.2174/157018009787847792	en
heal.publicationDate	2009	en
heal.abstract	Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong OH radical scavenging, where as benzoquinones with an ahydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition. © 2009 Bentham Science Publishers Ltd.	en
heal.journalName	Letters in Drug Design and Discovery	en
dc.identifier.issue	3	en
dc.identifier.volume	6	en
dc.identifier.doi	10.2174/157018009787847792	en
dc.identifier.spage	172	en
dc.identifier.epage	177	en