| dc.contributor.author |
Kotsampasi, B |
en |
| dc.contributor.author |
Balaskas, C |
en |
| dc.contributor.author |
Papadomichelakis, G |
en |
| dc.contributor.author |
Chadio, SE |
en |
| dc.date.accessioned |
2014-06-06T06:49:31Z |
|
| dc.date.available |
2014-06-06T06:49:31Z |
|
| dc.date.issued |
2009 |
en |
| dc.identifier.issn |
03784320 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/j.anireprosci.2008.08.017 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/4640 |
|
| dc.subject |
HPG axis |
en |
| dc.subject |
Male |
en |
| dc.subject |
Maternal undernutrition |
en |
| dc.subject |
Offspring |
en |
| dc.subject |
Sertoli cells |
en |
| dc.subject |
Sheep |
en |
| dc.subject.other |
follitropin |
en |
| dc.subject.other |
gonadorelin |
en |
| dc.subject.other |
luteinizing hormone |
en |
| dc.subject.other |
testosterone |
en |
| dc.subject.other |
animal |
en |
| dc.subject.other |
animal food |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
blood |
en |
| dc.subject.other |
cytology |
en |
| dc.subject.other |
drug effect |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
hypophysis |
en |
| dc.subject.other |
male |
en |
| dc.subject.other |
malnutrition |
en |
| dc.subject.other |
maternal nutrition |
en |
| dc.subject.other |
newborn |
en |
| dc.subject.other |
physiology |
en |
| dc.subject.other |
pregnancy |
en |
| dc.subject.other |
Sertoli cell |
en |
| dc.subject.other |
sexual maturation |
en |
| dc.subject.other |
sheep |
en |
| dc.subject.other |
weight gain |
en |
| dc.subject.other |
Animal Nutritional Physiological Phenomena |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Animals, Newborn |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Follicle Stimulating Hormone |
en |
| dc.subject.other |
Gonadotropin-Releasing Hormone |
en |
| dc.subject.other |
Luteinizing Hormone |
en |
| dc.subject.other |
Male |
en |
| dc.subject.other |
Malnutrition |
en |
| dc.subject.other |
Maternal Nutritional Physiological Phenomena |
en |
| dc.subject.other |
Pituitary Gland |
en |
| dc.subject.other |
Pregnancy |
en |
| dc.subject.other |
Sertoli Cells |
en |
| dc.subject.other |
Sexual Maturation |
en |
| dc.subject.other |
Sheep |
en |
| dc.subject.other |
Testosterone |
en |
| dc.subject.other |
Weight Gain |
en |
| dc.subject.other |
Animalia |
en |
| dc.subject.other |
Ovis aries |
en |
| dc.title |
Reduced Sertoli cell number and altered pituitary responsiveness in male lambs undernourished in utero |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/j.anireprosci.2008.08.017 |
en |
| heal.publicationDate |
2009 |
en |
| heal.abstract |
The nutritional status of females during pregnancy can have profound effects on the fetus reproductive system development that could affect the reproductive potential as later as in adulthood (fetal programming). The aim of the present study was to examine the effects of maternal nutrient restriction imposed during different periods of gestation on pituitary responsiveness at different ages postnatal and on Sertoli cell number in male offspring. Pregnant ewes were fed to 100% of Metabolizable Energy and Crude Protein requirements throughout pregnancy (Control) or to 50% from 0 to 30 (R1) or from 31 to 100 days of gestation (R2). Male lambs were selected and fed to appetite throughout the study. At 2, 5.5 and 10 months of age a GnRH challenge was conducted. At slaughter (10 months) testes were removed and examined histologically. Maternal undernutrition did not affect the time of the onset of puberty, defined as the first increase in plasma testosterone concentrations ≥1 ng/ml. The LH and FSH response to GnRH challenge did not differ between groups at 2 and 5.5 months but at 10 months of age a higher (P < 0.05) FSH response was found in R2 group. Testes weight did not differ between groups at slaughter. Mean Sertoli cell number was significantly lower in animals of R2 group compared with Control (P < 0.01). A smaller seminiferous tubules diameter was detected in R2 group (P < 0.05), while the diameter of the lumen was similar in all groups. Collectively, these results provide clear evidence for a direct effect of nutrient restriction during pregnancy on Sertoli cell number in adulthood. The lower number of Sertoli cells is the most candidate factor for the higher pituitary activity through a reduction in the suppressive effect of inhibin. © 2008 Elsevier B.V. All rights reserved. |
en |
| heal.journalName |
Animal Reproduction Science |
en |
| dc.identifier.issue |
1-3 |
en |
| dc.identifier.volume |
114 |
en |
| dc.identifier.doi |
10.1016/j.anireprosci.2008.08.017 |
en |
| dc.identifier.spage |
135 |
en |
| dc.identifier.epage |
147 |
en |