Effects of red wine on endothelial function: Postprandial studies vs clinical trials

dc.contributor.author	Karatzi, K	en
dc.contributor.author	Karatzis, E	en
dc.contributor.author	Papamichael, C	en
dc.contributor.author	Lekakis, J	en
dc.contributor.author	Zampelas, A	en
dc.date.accessioned	2014-06-06T06:49:22Z
dc.date.available	2014-06-06T06:49:22Z
dc.date.issued	2009	en
dc.identifier.issn	09394753	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.numecd.2009.04.006	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4552
dc.subject	Alcohol	en
dc.subject	Antioxidants	en
dc.subject	Endothelial function	en
dc.subject	FMD	en
dc.subject	Red wine	en
dc.subject.other	animal	en
dc.subject.other	clinical trial	en
dc.subject.other	coronary artery disease	en
dc.subject.other	human	en
dc.subject.other	pathophysiology	en
dc.subject.other	physiology	en
dc.subject.other	postprandial state	en
dc.subject.other	review	en
dc.subject.other	vascular endothelium	en
dc.subject.other	vasodilatation	en
dc.subject.other	wine	en
dc.subject.other	Animals	en
dc.subject.other	Clinical Trials as Topic	en
dc.subject.other	Coronary Artery Disease	en
dc.subject.other	Endothelium, Vascular	en
dc.subject.other	Humans	en
dc.subject.other	Postprandial Period	en
dc.subject.other	Vasodilation	en
dc.subject.other	Wine	en
dc.title	Effects of red wine on endothelial function: Postprandial studies vs clinical trials	en
heal.type	other	en
heal.identifier.primary	10.1016/j.numecd.2009.04.006	en
heal.publicationDate	2009	en
heal.abstract	Aims: There are several epidemiological studies suggesting that moderate daily consumption of red wine may reduce cardiovascular risk. Additionally, results from a great number of in vitro studies indicate that constituents found in red wine are responsible for quite a few beneficial effects on endothelial cells. However, comparison of postprandial studies and clinical trials concerning red wine consumption leads to controversial results about its effect on endothelial function and especially flow-mediated dilatation (FMD). Endothelial function is an early indicator of atherosclerosis and vessel damage and at the same time, it is an independent prognostic factor for cardiovascular risk. Therefore, it is very important to investigate the known acute postprandial effects of red wine consumption, which is highly advised by dieticians and doctors, especially in high-risk populations, such as patients with coronary artery disease (CAD). Data synthesis: This is a review of studies investigating acute and short-term effects of red wine on endothelial function, as well as relevant in vitro studies. Conclusion: Analysis of all data about the acute effects of red wine constituents on endothelial function, is inconclusive and it is obvious that new studies are necessary in order to elucidate this matter. Undoubtedly, one should be very careful in suggesting red wine consumption in high-risk populations, as its acute postprandial effect is not yet clear. © 2009 Elsevier B.V. All rights reserved.	en
heal.journalName	Nutrition, Metabolism and Cardiovascular Diseases	en
dc.identifier.issue	10	en
dc.identifier.volume	19	en
dc.identifier.doi	10.1016/j.numecd.2009.04.006	en
dc.identifier.spage	744	en
dc.identifier.epage	750	en