| dc.contributor.author |
Kotsampasi, B |
en |
| dc.contributor.author |
Chadio, S |
en |
| dc.contributor.author |
Papadomichelakis, G |
en |
| dc.contributor.author |
Deligeorgis, S |
en |
| dc.contributor.author |
Kalogiannis, D |
en |
| dc.contributor.author |
Menegatos, I |
en |
| dc.contributor.author |
Zervas, G |
en |
| dc.date.accessioned |
2014-06-06T06:49:22Z |
|
| dc.date.available |
2014-06-06T06:49:22Z |
|
| dc.date.issued |
2009 |
en |
| dc.identifier.issn |
09366768 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1111/j.1439-0531.2007.01046.x |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/4550 |
|
| dc.subject.other |
diagnostic agent |
en |
| dc.subject.other |
follitropin |
en |
| dc.subject.other |
gonadorelin |
en |
| dc.subject.other |
luteinizing hormone |
en |
| dc.subject.other |
aging |
en |
| dc.subject.other |
animal |
en |
| dc.subject.other |
animal disease |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
blood |
en |
| dc.subject.other |
corpus luteum |
en |
| dc.subject.other |
drug effect |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
gestational age |
en |
| dc.subject.other |
histology |
en |
| dc.subject.other |
hypophysis |
en |
| dc.subject.other |
hypothalamus |
en |
| dc.subject.other |
malnutrition |
en |
| dc.subject.other |
ovary |
en |
| dc.subject.other |
ovary follicle |
en |
| dc.subject.other |
physiology |
en |
| dc.subject.other |
pregnancy |
en |
| dc.subject.other |
prenatal exposure |
en |
| dc.subject.other |
sexual maturation |
en |
| dc.subject.other |
sheep |
en |
| dc.subject.other |
Aging |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Corpus Luteum |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Follicle Stimulating Hormone |
en |
| dc.subject.other |
Gestational Age |
en |
| dc.subject.other |
Gonadotropin-Releasing Hormone |
en |
| dc.subject.other |
Hypothalamus |
en |
| dc.subject.other |
Luteinizing Hormone |
en |
| dc.subject.other |
Malnutrition |
en |
| dc.subject.other |
Ovarian Follicle |
en |
| dc.subject.other |
Ovary |
en |
| dc.subject.other |
Pituitary Gland |
en |
| dc.subject.other |
Pregnancy |
en |
| dc.subject.other |
Prenatal Exposure Delayed Effects |
en |
| dc.subject.other |
Sexual Maturation |
en |
| dc.subject.other |
Sheep |
en |
| dc.subject.other |
Ovis aries |
en |
| dc.title |
Effects of maternal undernutrition on the hypothalamic-pituitary-gonadal axis function in female sheep offspring |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1111/j.1439-0531.2007.01046.x |
en |
| heal.publicationDate |
2009 |
en |
| heal.abstract |
Contents A study was conducted to evaluate the effects of maternal undernutrition on the hypothalamic-pituitary-gonadal axis in female sheep offspring. Pregnant ewes were fed to 100% throughout pregnancy (Control) or to 50% from 0 to 30 (R1) or from 31 to 100 days of gestation (R2). Female lambs were selected and fed to appetite throughout the study. At 2, 5.5 and 10 months of age a GnRH challenge was conducted. At the age of 10 months lambs were synchronized and blood samples were collected at 3 h intervals for 72 h following sponge removal. At slaughter (10 months) ovaries were removed and examined macroscopically. Maternal undernutrition did not affect the time of the onset of puberty, defined as the first increase in plasma progesterone concentrations ≥1 ng/ml. The magnitude of the pre-ovulatory gonadotrophin surge and the time to surge were unaffected by treatment. The LH and FSH response to GnRH challenge did not differ between groups at 2 and 5.5 months but at 10 months of age a higher (p < 0.05) FSH response was found in R1 group. Although the total number of visible follicles and corpora lutea did not differ between groups, a significant higher (p < 0.05) number of small (2-3 mm diameter) follicles in R1 group and a significant lower number (p < 0.05) of corpora lutea with diameter 8-11 mm and not even one with diameter >12 mm were detected in the ovaries of R2 lambs. In conclusion, maternal undernutrition during the first month of pregnancy resulted in increased pituitary sensitivity to GnRH and increased number of small follicles in the ovary, while during mid to late gestation resulted in a reduction of large corpora lutea in female offspring. © 2008 Blackwell Verlag. |
en |
| heal.journalName |
Reproduction in Domestic Animals |
en |
| dc.identifier.issue |
4 |
en |
| dc.identifier.volume |
44 |
en |
| dc.identifier.doi |
10.1111/j.1439-0531.2007.01046.x |
en |
| dc.identifier.spage |
677 |
en |
| dc.identifier.epage |
684 |
en |