Combined administration of gonadotropin-releasing hormone, progesterone, and meloxicam is an effective treatment for the repeat-breeder cow

dc.contributor.author	Amiridis, GS	en
dc.contributor.author	Tsiligianni, Th	en
dc.contributor.author	Dovolou, E	en
dc.contributor.author	Rekkas, C	en
dc.contributor.author	Vouzaras, D	en
dc.contributor.author	Menegatos, I	en
dc.date.accessioned	2014-06-06T06:49:17Z
dc.date.available	2014-06-06T06:49:17Z
dc.date.issued	2009	en
dc.identifier.issn	0093691X	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.theriogenology.2009.04.010	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4510
dc.subject	GnRH	en
dc.subject	Meloxicam	en
dc.subject	NSAID	en
dc.subject	Progesterone	en
dc.subject	Repeat-breeder cow	en
dc.subject.other	gonadorelin	en
dc.subject.other	meloxicam	en
dc.subject.other	progesterone	en
dc.subject.other	thiazine derivative	en
dc.subject.other	thiazole derivative	en
dc.subject.other	animal	en
dc.subject.other	animal disease	en
dc.subject.other	article	en
dc.subject.other	breeding	en
dc.subject.other	cattle	en
dc.subject.other	cattle disease	en
dc.subject.other	estrus cycle	en
dc.subject.other	female	en
dc.subject.other	female infertility	en
dc.subject.other	methodology	en
dc.subject.other	pregnancy	en
dc.subject.other	pregnancy rate	en
dc.subject.other	Animals	en
dc.subject.other	Breeding	en
dc.subject.other	Cattle	en
dc.subject.other	Cattle Diseases	en
dc.subject.other	Estrous Cycle	en
dc.subject.other	Female	en
dc.subject.other	Gonadotropin-Releasing Hormone	en
dc.subject.other	Infertility, Female	en
dc.subject.other	Pregnancy	en
dc.subject.other	Pregnancy Rate	en
dc.subject.other	Progesterone	en
dc.subject.other	Thiazines	en
dc.subject.other	Thiazoles	en
dc.title	Combined administration of gonadotropin-releasing hormone, progesterone, and meloxicam is an effective treatment for the repeat-breeder cow	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.theriogenology.2009.04.010	en
heal.publicationDate	2009	en
heal.abstract	In practice, the etiologic treatment of the repeat-breeder cow is nearly infeasible. In this study, we tested the hypothesis that a combined treatment would benefit the conception rate of repeat-breeder cows. The components of this regimen target ovulation defects, late progesterone (P4) rise, and premature luteolysis. In a 5-year period, 402 repeat-breeder cows were divided in five groups, and treatment regimens consisted of the following: gonadotropin-releasing hormone (GnRH; Group 1, n = 115, 0.012 mg buserelin im 4 to 6 h before artificial insemination); P4 (Group 2, n = 51, 100 mg P4 intravaginally, on Days 5 to 7); meloxicam (Group 3, n = 31, 0.5 mg kg-1, 24 h-1 melοxicam sc, on Days 16 to 18); GnRH + P4 + meloxicam (Group 4, n = 98); and no treatment (Group 5, control, n = 107). Artificial insemination was conducted only after overt estrus; thereafter, the duration of the estrous cycle was assessed in all cows that were detected to return to heat. The conception and pregnancy rate was compared among groups. The proportion of cows that returned to estrus after artificial insemination did not differ among groups; the duration of estrous cycle was the shortest in Group 1 and the longest in Group 4. In Group 4, pregnancy rate was higher (P < 0.05) than that of Groups 1 and 5 (35.71% vs. 20.00% and 17.76% for Groups 4, 1, and 5, respectively), but though numerically higher, it did not differ statistically from that of Groups 2 (27.45%) and 3 (22.58%). Our results imply that a multifaceted protocol has to be applied for the successful treatment of the repeat-breeder cow. © 2009.	en
heal.journalName	Theriogenology	en
dc.identifier.issue	4	en
dc.identifier.volume	72	en
dc.identifier.doi	10.1016/j.theriogenology.2009.04.010	en
dc.identifier.spage	542	en
dc.identifier.epage	548	en