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Fabrication and characterization of a multiwell array SERS chip with biological applications

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dc.contributor.author Abell, JL en
dc.contributor.author Driskell, JD en
dc.contributor.author Dluhy, RA en
dc.contributor.author Tripp, RA en
dc.contributor.author Zhao, Y-P en
dc.date.accessioned 2014-06-06T06:48:57Z
dc.date.available 2014-06-06T06:48:57Z
dc.date.issued 2009 en
dc.identifier.issn 09565663 en
dc.identifier.uri http://dx.doi.org/10.1016/j.bios.2009.05.039 en
dc.identifier.uri http://62.217.125.90/xmlui/handle/123456789/4354
dc.subject Microtiter en
dc.subject Multiwell array en
dc.subject Patterned substrate en
dc.subject SERS en
dc.subject Silver nanorod array en
dc.subject Viral detection en
dc.subject.other Microtiter en
dc.subject.other Multiwell array en
dc.subject.other Patterned substrate en
dc.subject.other SERS en
dc.subject.other Silver nanorod array en
dc.subject.other Viral detection en
dc.subject.other Biosensors en
dc.subject.other Decision making en
dc.subject.other Ethylene en
dc.subject.other Multivariant analysis en
dc.subject.other Nanorods en
dc.subject.other Raman spectroscopy en
dc.subject.other Silver en
dc.subject.other Surfaces en
dc.subject.other Substrates en
dc.subject.other 1,2 di(4 pyridyl)ethylene en
dc.subject.other ethylene derivative en
dc.subject.other unclassified drug en
dc.subject.other article en
dc.subject.other biochip en
dc.subject.other biosensor en
dc.subject.other controlled study en
dc.subject.other Influenza virus en
dc.subject.other nonhuman en
dc.subject.other polymerization en
dc.subject.other reproducibility en
dc.subject.other signal detection en
dc.subject.other signal processing en
dc.subject.other spectroscopy en
dc.subject.other surface enhanced raman spectroscopy en
dc.subject.other virus detection en
dc.subject.other Biology en
dc.subject.other Biosensing Techniques en
dc.subject.other Equipment Design en
dc.subject.other Equipment Failure Analysis en
dc.subject.other Microarray Analysis en
dc.subject.other Surface Plasmon Resonance en
dc.subject.other Aves en
dc.title Fabrication and characterization of a multiwell array SERS chip with biological applications en
heal.type journalArticle en
heal.identifier.primary 10.1016/j.bios.2009.05.039 en
heal.publicationDate 2009 en
heal.abstract Uniform, large surface area substrates for surface-enhanced Raman spectroscopy (SERS) are fabricated by oblique angle deposition. The SERS-active substrates are patterned by a polymer-molding technique to provide a uniform array for high throughput biosensing and multiplexing. Using a conventional SERS-active molecule, 1,2-di(4-pyridyl)ethylene (BPE) ≥98%, we show that this device provides a uniform Raman signal enhancement from well to well with a detection limit of at least 10-8 M of the BPE solution or 10-18 mol of BPE. The SERS intensity is also demonstrated to vary logarithmically with the log of BPE concentration and the apparent sensitivity of the patterned substrate is compared to previous reports from our group on non-patterned substrates. Avian influenza is analyzed to demonstrate the utility of SERS multiwell patterned substrates for biosensing. The spectra acquired from patterned substrates show better reproducibility and less variation compared to the unpatterned substrates according to multivariate analysis. Our results highlight potential advantages of the patterned substrate. © 2009 Elsevier B.V. All rights reserved. en
heal.journalName Biosensors and Bioelectronics en
dc.identifier.issue 12 en
dc.identifier.volume 24 en
dc.identifier.doi 10.1016/j.bios.2009.05.039 en
dc.identifier.spage 3663 en
dc.identifier.epage 3670 en


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