| dc.contributor.author |
Antonopoulou, G |
en |
| dc.contributor.author |
Magrioti, V |
en |
| dc.contributor.author |
Stephens, D |
en |
| dc.contributor.author |
Constantinou-Kokotou, V |
en |
| dc.contributor.author |
Dennis, EA |
en |
| dc.contributor.author |
Kokotos, G |
en |
| dc.date.accessioned |
2014-06-06T06:48:51Z |
|
| dc.date.available |
2014-06-06T06:48:51Z |
|
| dc.date.issued |
2008 |
en |
| dc.identifier.issn |
10752617 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1002/psc.1048 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/4303 |
|
| dc.subject |
2-oxoamides |
en |
| dc.subject |
Acyl sulfonamides |
en |
| dc.subject |
Inhibitors |
en |
| dc.subject |
Phospholipase A2 |
en |
| dc.subject |
Sulfonamides |
en |
| dc.subject.other |
2 hydroxy n [1 (4 methylphenylsulfonamido)octan 4 yl]hexadecanamide |
en |
| dc.subject.other |
2 hydroxy n [1 (methylphenylsulfonamido)octan 4 yl]hexadecanamide |
en |
| dc.subject.other |
2 hydroxy n [3 (4 methylphenylsulfonamido)propyl]hexadecanamide |
en |
| dc.subject.other |
2 hydroxy n [3 (methylsulfonamido)propyl]hexadecanamide |
en |
| dc.subject.other |
2 hydroxy n [4 (4 methylphenylsulfonamido) 4 oxobutyl]hexadecanamide |
en |
| dc.subject.other |
2 hydroxy n [4 (4 methylphenylsulfonamido)butyl]hexadecanamide |
en |
| dc.subject.other |
2 hydroxy n [4 (methylsulfonamido) 4 oxobutyl]hexadecanamide |
en |
| dc.subject.other |
2 hydroxy n [4 (methylsulfonamido)butyl]hexadecanamide |
en |
| dc.subject.other |
2 oxoamide derivative |
en |
| dc.subject.other |
4 aminobutyric acid |
en |
| dc.subject.other |
ax 006 |
en |
| dc.subject.other |
ax 007 |
en |
| dc.subject.other |
ax 048 |
en |
| dc.subject.other |
ax 109 |
en |
| dc.subject.other |
enzyme inhibitor |
en |
| dc.subject.other |
group 4 secreted phospholipase A2 |
en |
| dc.subject.other |
group 6a calcium independent phospholipase A2 |
en |
| dc.subject.other |
n (3 aminopropyl) 4 methylbenzenesulfonamide |
en |
| dc.subject.other |
n (4 aminobutyl) 4 methylbenzenesulfonamide |
en |
| dc.subject.other |
phospholipase A2 |
en |
| dc.subject.other |
phospholipase A2 inhibitor |
en |
| dc.subject.other |
tert butyl 1 (4 methylphenylsulfonamido)octan 4 ylcarbamate |
en |
| dc.subject.other |
tert butyl 1 (methylsulfonamido)octan 4 ylcarbamate |
en |
| dc.subject.other |
tert butyl 1 cyanohept 1 en 3 ylcarbamate |
en |
| dc.subject.other |
tert butyl 1 cyanoheptan 3 ylcarbamate |
en |
| dc.subject.other |
tert butyl 4 (4 methylphenylsulfonamido) 4 oxobutylcarbamate |
en |
| dc.subject.other |
tert butyl 4 (methylsulfonamido) 4 oxobutylcarbamate |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
drug structure |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
enzyme inhibition |
en |
| dc.subject.other |
human |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
structure activity relation |
en |
| dc.subject.other |
Amino Acids |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Isoenzymes |
en |
| dc.subject.other |
Phospholipases A2 |
en |
| dc.subject.other |
Pyridines |
en |
| dc.subject.other |
Sulfonamides |
en |
| dc.title |
Synthesis of 2-oxoamides based on sulfonamide analogs of γ-amino acids and their activty on phospholipase A2 |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1002/psc.1048 |
en |
| heal.publicationDate |
2008 |
en |
| heal.abstract |
A variety of lipophilic 2-oxoamides containing sulfonamide analogs of γ-amino acids as well as acyl sulfonamides of γ-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA2 and GVIA iPLA2 as well as secreted GV sPLA2 was evaluated. The sulfonamide group seems a bioisosteric group suitable to replace the carboxyl group in 2-oxoamide inhibitors of GVIA cPLA2. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd. |
en |
| heal.journalName |
Journal of Peptide Science |
en |
| dc.identifier.issue |
10 |
en |
| dc.identifier.volume |
14 |
en |
| dc.identifier.doi |
10.1002/psc.1048 |
en |
| dc.identifier.spage |
1111 |
en |
| dc.identifier.epage |
1120 |
en |