Selenoproteins and maternal nutrition

dc.contributor.author	Pappas, AC	en
dc.contributor.author	Zoidis, E	en
dc.contributor.author	Surai, PF	en
dc.contributor.author	Zervas, G	en
dc.date.accessioned	2014-06-06T06:48:40Z
dc.date.available	2014-06-06T06:48:40Z
dc.date.issued	2008	en
dc.identifier.issn	10964959	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.cbpb.2008.08.009	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4230
dc.subject	Antioxidants	en
dc.subject	Gene expression	en
dc.subject	Maternal nutrition	en
dc.subject	Progeny	en
dc.subject	Selenium	en
dc.subject	Selenoproteins	en
dc.subject.other	glutathione peroxidase	en
dc.subject.other	iodothyronine deiodinase	en
dc.subject.other	methionine sulfoxide reductase B	en
dc.subject.other	phospholipid hydroperoxide glutathione peroxidase	en
dc.subject.other	selenophosphate synthetase	en
dc.subject.other	selenoprotein	en
dc.subject.other	selenoprotein H	en
dc.subject.other	selenoprotein I	en
dc.subject.other	selenoprotein J	en
dc.subject.other	selenoprotein K	en
dc.subject.other	selenoprotein M	en
dc.subject.other	selenoprotein N	en
dc.subject.other	selenoprotein O	en
dc.subject.other	selenoprotein P	en
dc.subject.other	selenoprotein S	en
dc.subject.other	selenoprotein t	en
dc.subject.other	selenoprotein U	en
dc.subject.other	selenoprotein V	en
dc.subject.other	selenoprotein W	en
dc.subject.other	thioredoxin reductase	en
dc.subject.other	unclassified drug	en
dc.subject.other	antioxidant activity	en
dc.subject.other	diet supplementation	en
dc.subject.other	female	en
dc.subject.other	gene expression	en
dc.subject.other	human	en
dc.subject.other	lactation	en
dc.subject.other	maternal nutrition	en
dc.subject.other	nonhuman	en
dc.subject.other	oxidation reduction reaction	en
dc.subject.other	postnatal care	en
dc.subject.other	prenatal care	en
dc.subject.other	priority journal	en
dc.subject.other	progeny	en
dc.subject.other	review	en
dc.subject.other	transcription regulation	en
dc.subject.other	Animals	en
dc.subject.other	Antioxidants	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Lactation	en
dc.subject.other	Maternal Nutritional Physiological Phenomena	en
dc.subject.other	Nutritional Status	en
dc.subject.other	Pregnancy	en
dc.subject.other	Selenium	en
dc.subject.other	Selenoproteins	en
dc.subject.other	Transcription, Genetic	en
dc.title	Selenoproteins and maternal nutrition	en
heal.type	other	en
heal.identifier.primary	10.1016/j.cbpb.2008.08.009	en
heal.publicationDate	2008	en
heal.abstract	Selenium (Se) is an essential trace element of fundamental importance to health due to its antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence within at least 25 selenoproteins (Sel). Sel include but not limited to glutathione peroxidases (GPx1-GPx6), thioredoxin reductases (TrxR1-TrxR3), iodothyronine deiodinases (ID1-ID3), selenophosphate synthetase 2 (SPS2), 15-kDa Sel (Sel15), SelH, SelI, SelK, SelM, SelN, SelO, SelP, SelR, SelS, SelT, SelV, SelW, as well as the 15-kDa Sel (Fep15), SelJ and SelU found in fish. In this review, we describe some of the recent progress in our understanding of the mechanisms of Sel synthesis. The impact of maternal Se intake on offspring is also discussed. The key regulatory point of Sel synthesis is Se itself, which acts predominantly at post-transcriptional levels, although recent findings indicate transcriptional and redox regulation. Maternal nutrition affects the performance and health of the progeny. Both maternal and offspring Se supplementations are essential for the antioxidant protection of the offspring. Prenatal Se supplementation provides an effective antioxidant system that is already in place at the time of birth while, postnatal Se supplementation becomes the main determinant of progeny Se status after the first few days of progeny life. © 2008 Elsevier Inc. All rights reserved.	en
heal.journalName	Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology	en
dc.identifier.issue	4	en
dc.identifier.volume	151	en
dc.identifier.doi	10.1016/j.cbpb.2008.08.009	en
dc.identifier.spage	361	en
dc.identifier.epage	372	en