Postprandial improvement of endothelial function by red wine and olive oil antioxidants: A synergistic effect of components of the mediterranean diet

dc.contributor.author	Karatzi, K	en
dc.contributor.author	Papamichael, C	en
dc.contributor.author	Karatzis, E	en
dc.contributor.author	Papaioannou, TG	en
dc.contributor.author	Voidonikola, PTh	en
dc.contributor.author	Vamvakou, GD	en
dc.contributor.author	Lekakis, J	en
dc.contributor.author	Zampelas, A	en
dc.date.accessioned	2014-06-06T06:48:39Z
dc.date.available	2014-06-06T06:48:39Z
dc.date.issued	2008	en
dc.identifier.issn	07315724	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4222
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-58749109183&partnerID=40&md5=78b9886537c1ed53b72a08a127f870dd	en
dc.subject	FMD	en
dc.subject	Mediterranean diet	en
dc.subject	Olive oil	en
dc.subject	Wine	en
dc.subject.other	antioxidant	en
dc.subject.other	olive oil	en
dc.subject.other	antioxidant	en
dc.subject.other	olive oil	en
dc.subject.other	vegetable oil	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	comparative study	en
dc.subject.other	controlled study	en
dc.subject.other	device	en
dc.subject.other	diet restriction	en
dc.subject.other	endothelium	en
dc.subject.other	female	en
dc.subject.other	human	en
dc.subject.other	male	en
dc.subject.other	meal	en
dc.subject.other	Mediterranean diet	en
dc.subject.other	postprandial state	en
dc.subject.other	red wine	en
dc.subject.other	ultrasound	en
dc.subject.other	analysis of variance	en
dc.subject.other	cardiovascular disease	en
dc.subject.other	clinical trial	en
dc.subject.other	drug effect	en
dc.subject.other	physiology	en
dc.subject.other	postprandial state	en
dc.subject.other	vasodilatation	en
dc.subject.other	wine	en
dc.subject.other	Adult	en
dc.subject.other	Analysis of Variance	en
dc.subject.other	Antioxidants	en
dc.subject.other	Cardiovascular Diseases	en
dc.subject.other	Diet, Mediterranean	en
dc.subject.other	Endothelium	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Plant Oils	en
dc.subject.other	Postprandial Period	en
dc.subject.other	Vasodilation	en
dc.subject.other	Wine	en
dc.title	Postprandial improvement of endothelial function by red wine and olive oil antioxidants: A synergistic effect of components of the mediterranean diet	en
heal.type	journalArticle	en
heal.publicationDate	2008	en
heal.abstract	Objective: Consumption of olive oil may cause postprandial impairment of endothelial function, while acute ingestion of red wine seems to improve it. The purpose of the present study was to investigate the combined postprandial effects of two essential components of the Mediterranean diet, red wine and olive oil, on endothelial function. Methods: Fifteen healthy subjects were enrolled in the study, which was comprised of 4 study days. Subjects were asked to consume a standard meal at each study day containing 50gr of olive oil and 250 ml of wine. Two types of wine (red and white; rich and poor in antioxidants respectively) and two types of olive oil (green and refined; rich and poor in antioxidants respectively) were used in a 2*2 design. Endothelium dependent, flow mediated dilatation (FMD) was measured with a B-Mode ultrasound device at fast and 1, 2 and 3 hours postprandially. Results: Combined consumption of red wine and green olive oil (both rich in antioxidants) improved FMD postprandially (p = 0.002, ANOVA for repeated measures), which remained significant 1 hour (p = 0.002) and 2 hours (0.037) following the meal compared to fasting levels. No other combination of wine and olive oil caused any significant alteration on FMD. Conclusion: Acute consumption of both red wine and green olive oil, rich in antioxidants, led to an improvement in the postprandial endothelial function in healthy subjects. These findings provide an additional favorable effect of components of the Mediterranean diet and of their antioxidant substances on endothelial function, at the postprandial state.	en
heal.journalName	Journal of the American College of Nutrition	en
dc.identifier.issue	4	en
dc.identifier.volume	27	en
dc.identifier.spage	448	en
dc.identifier.epage	453	en