PIFA-mediated synthesis of novel pyrazoloquinolin-4-ones as potential ligands for the estrogen receptor

dc.contributor.author	Christodoulou, MS	en
dc.contributor.author	Kasiotis, KM	en
dc.contributor.author	Fokialakis, N	en
dc.contributor.author	Tellitu, I	en
dc.contributor.author	Haroutounian, SA	en
dc.date.accessioned	2014-06-06T06:48:39Z
dc.date.available	2014-06-06T06:48:39Z
dc.date.issued	2008	en
dc.identifier.issn	00404039	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.tetlet.2008.09.098	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4221
dc.subject	Estrogen receptor	en
dc.subject	PIFA	en
dc.subject	Pyrazole	en
dc.subject	Quinolin-4-ones	en
dc.subject.other	estrogen receptor	en
dc.subject.other	ligand	en
dc.subject.other	phenyliodine bis(trifluoroacetate)	en
dc.subject.other	pyrazoloquinolin 4 one	en
dc.subject.other	trifluoroacetic acid	en
dc.subject.other	unclassified drug	en
dc.subject.other	amidation	en
dc.subject.other	article	en
dc.subject.other	cyclization	en
dc.subject.other	reaction analysis	en
dc.subject.other	synthesis	en
dc.title	PIFA-mediated synthesis of novel pyrazoloquinolin-4-ones as potential ligands for the estrogen receptor	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.tetlet.2008.09.098	en
heal.publicationDate	2008	en
heal.abstract	A facile and efficient preparation of pyrazoloquinolin-4-ones, as potential ligands for the estrogen receptor, via a PIFA [phenyliodine(III)bis(trifluoroacetate)] promoted cyclization reaction with overall yields up to 29% over six steps is described. The employed strategy, based on an electrophilic amidation reaction as the key step of the synthesis, allows the generation of a diverse array of derivatives. © 2008 Elsevier Ltd. All rights reserved.	en
heal.journalName	Tetrahedron Letters	en
dc.identifier.issue	50	en
dc.identifier.volume	49	en
dc.identifier.doi	10.1016/j.tetlet.2008.09.098	en
dc.identifier.spage	7100	en
dc.identifier.epage	7102	en