| dc.contributor.author |
Zieminska, E |
en |
| dc.contributor.author |
Lazarewicz, JW |
en |
| dc.contributor.author |
Couladouros, EA |
en |
| dc.contributor.author |
Moutsos, VI |
en |
| dc.contributor.author |
Pitsinos, EN |
en |
| dc.date.accessioned |
2014-06-06T06:48:37Z |
|
| dc.date.available |
2014-06-06T06:48:37Z |
|
| dc.date.issued |
2008 |
en |
| dc.identifier.issn |
0960894X |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/j.bmcl.2008.09.080 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/4211 |
|
| dc.subject |
Bastadins |
en |
| dc.subject |
Calcium channels |
en |
| dc.subject |
Cerebellar granule cells |
en |
| dc.subject |
Diaryl ether |
en |
| dc.subject |
Ryanodine |
en |
| dc.subject.other |
bastadin 5 |
en |
| dc.subject.other |
bastadin derivative |
en |
| dc.subject.other |
calcium |
en |
| dc.subject.other |
natural product |
en |
| dc.subject.other |
ryanodine receptor 2 |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
animal cell |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
calcium homeostasis |
en |
| dc.subject.other |
calcium transport |
en |
| dc.subject.other |
drug structure |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
nerve cell culture |
en |
| dc.subject.other |
nonhuman |
en |
| dc.subject.other |
rat |
en |
| dc.subject.other |
structure analysis |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Calcium |
en |
| dc.subject.other |
Cells, Cultured |
en |
| dc.subject.other |
Cyclization |
en |
| dc.subject.other |
Halogenated Diphenyl Ethers |
en |
| dc.subject.other |
Homeostasis |
en |
| dc.subject.other |
Neurons |
en |
| dc.subject.other |
Protein Conformation |
en |
| dc.subject.other |
Rats |
en |
| dc.title |
Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/j.bmcl.2008.09.080 |
en |
| heal.publicationDate |
2008 |
en |
| heal.abstract |
Constraining the catechol aryl ether moiety of bastadins by incorporation into a macrocyle is not necessary in order to mimic the effects of these marine natural products on neuronal calcium homeostasis. Simple, acyclic analogs that embody the 'western' or 'eastern' parts of bastadins were found to evoke comparable responses with bastadin 5. © 2008 Elsevier Ltd. All rights reserved. |
en |
| heal.journalName |
Bioorganic and Medicinal Chemistry Letters |
en |
| dc.identifier.issue |
21 |
en |
| dc.identifier.volume |
18 |
en |
| dc.identifier.doi |
10.1016/j.bmcl.2008.09.080 |
en |
| dc.identifier.spage |
5734 |
en |
| dc.identifier.epage |
5737 |
en |