Combined administration in a single injection of a feline multivalent modified live vaccine against FHV, FCV, and FPLV together with a recombinant FeLV vaccine is both safe and efficacious for all four major feline viral pathogens

dc.contributor.author	Kanellos, T	en
dc.contributor.author	Sutton, DJ	en
dc.contributor.author	Salisbury, CF	en
dc.contributor.author	Chalmers, WilliamSK	en
dc.date.accessioned	2014-06-06T06:48:23Z
dc.date.available	2014-06-06T06:48:23Z
dc.date.issued	2008	en
dc.identifier.issn	1098612X	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.jfms.2008.02.001	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/4121
dc.subject.other	live vaccine	en
dc.subject.other	vaccine	en
dc.subject.other	virus vaccine	en
dc.subject.other	animal	en
dc.subject.other	animal disease	en
dc.subject.other	article	en
dc.subject.other	cat	en
dc.subject.other	cat disease	en
dc.subject.other	Feline leukemia virus	en
dc.subject.other	Feline panleukopenia virus	en
dc.subject.other	female	en
dc.subject.other	Herpes virus	en
dc.subject.other	Herpes virus infection	en
dc.subject.other	immunology	en
dc.subject.other	male	en
dc.subject.other	safety	en
dc.subject.other	treatment outcome	en
dc.subject.other	Vesivirus	en
dc.subject.other	virus infection	en
dc.subject.other	Animals	en
dc.subject.other	Caliciviridae Infections	en
dc.subject.other	Calicivirus, Feline	en
dc.subject.other	Cat Diseases	en
dc.subject.other	Cats	en
dc.subject.other	Feline Panleukopenia	en
dc.subject.other	Feline panleukopenia virus	en
dc.subject.other	Female	en
dc.subject.other	Herpesviridae	en
dc.subject.other	Herpesviridae Infections	en
dc.subject.other	Leukemia Virus, Feline	en
dc.subject.other	Leukemia, Feline	en
dc.subject.other	Male	en
dc.subject.other	Safety	en
dc.subject.other	Treatment Outcome	en
dc.subject.other	Vaccines, Attenuated	en
dc.subject.other	Vaccines, Combined	en
dc.subject.other	Viral Vaccines	en
dc.subject.other	Caliciviridae	en
dc.subject.other	Felidae	en
dc.subject.other	Feline calicivirus	en
dc.subject.other	Feline panleukopenia virus	en
dc.subject.other	Herpesviridae	en
dc.title	Combined administration in a single injection of a feline multivalent modified live vaccine against FHV, FCV, and FPLV together with a recombinant FeLV vaccine is both safe and efficacious for all four major feline viral pathogens	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.jfms.2008.02.001	en
heal.publicationDate	2008	en
heal.abstract	Nobivac Tricat, a lyophilised trivalent modified live attenuated vaccine is routinely used to protect cats against three commonly diagnosed feline viral pathogens namely herpesvirus, calicivirus and panleukopenia virus. The recognition of feline leukaemia virus (FeLV) as an important viral pathogen has prompted the development of an efficacious liquid recombinant subunit FeLV vaccine (p45 envelope protein). Lyophilised Tricat vaccine was dissolved in the liquid FeLV vaccine and no detectable deleterious effect on the titre of any of the live virus components was observed after 2h incubation. In vivo studies where the vaccines were mixed in the same syringe prior to inoculation showed no alteration to the safety profile assessed by repeat and overdose studies. Serological comparisons of the modified live viral antibody titres showed no evidence of reduced responses following administration of the mixed products. Challenge studies using pathogenic herpesvirus and FeLV revealed no difference in the degree of clinical protection. This paper shows that neither safety nor efficacy is adversely affected as a result of mixing the two vaccines. © 2008 ESFM and AAFP.	en
heal.journalName	Journal of Feline Medicine and Surgery	en
dc.identifier.issue	4	en
dc.identifier.volume	10	en
dc.identifier.doi	10.1016/j.jfms.2008.02.001	en
dc.identifier.spage	346	en
dc.identifier.epage	354	en