| dc.contributor.author |
Antonopoulou, G |
en |
| dc.contributor.author |
Magrioti, V |
en |
| dc.contributor.author |
Stephens, D |
en |
| dc.contributor.author |
Constantinou-Kokotou, V |
en |
| dc.contributor.author |
Dennis, EA |
en |
| dc.contributor.author |
Kokotos, G |
en |
| dc.date.accessioned |
2014-06-06T06:48:15Z |
|
| dc.date.available |
2014-06-06T06:48:15Z |
|
| dc.date.issued |
2008 |
en |
| dc.identifier.issn |
1075-2617 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/4039 |
|
| dc.subject |
acyl sulfonamides |
en |
| dc.subject |
inhibitors |
en |
| dc.subject |
2-oxoamides |
en |
| dc.subject |
phospholipase A(2) |
en |
| dc.subject |
sulfonamides |
en |
| dc.subject.classification |
Biochemistry & Molecular Biology |
en |
| dc.subject.classification |
Chemistry, Analytical |
en |
| dc.subject.other |
ONE-POT CONVERSION |
en |
| dc.subject.other |
GROUP-IVA |
en |
| dc.subject.other |
GROUP-V |
en |
| dc.subject.other |
ARACHIDONIC-ACID |
en |
| dc.subject.other |
ALDOL REACTIONS |
en |
| dc.subject.other |
GROUP-IIA |
en |
| dc.subject.other |
INHIBITORS |
en |
| dc.subject.other |
RELEASE |
en |
| dc.subject.other |
CELLS |
en |
| dc.subject.other |
SUPERFAMILY |
en |
| dc.title |
Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A(2) |
en |
| heal.type |
journalArticle |
en |
| heal.language |
English |
en |
| heal.publicationDate |
2008 |
en |
| heal.abstract |
A variety of lipophilic 2-oxoamides containing sulfonamide analogs of gamma-amino acids as well as acyl sulfonamides of gamma-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA(2) and GVIA iPLA(2) as well as secreted GV sPLA(2) was evaluated. The sulfonamide group seems a bioisosteric group suitable to replace the carboxyl group in 2-oxoamide inhibitors of GVIA cPLA(2). Copyright, (C) 2008 European Peptide Society and John Wiley & Sons, Ltd.. |
en |
| heal.publisher |
JOHN WILEY & SONS LTD |
en |
| heal.journalName |
JOURNAL OF PEPTIDE SCIENCE |
en |
| dc.identifier.issue |
10 |
en |
| dc.identifier.volume |
14 |
en |
| dc.identifier.isi |
ISI:000260101500005 |
en |
| dc.identifier.spage |
1111 |
en |
| dc.identifier.epage |
1120 |
en |