| dc.contributor.author |
Smith, MA |
en |
| dc.contributor.author |
Takeuchi, K |
en |
| dc.contributor.author |
Anderson, G |
en |
| dc.contributor.author |
Ware, GO |
en |
| dc.contributor.author |
McClure, HM |
en |
| dc.contributor.author |
Raybourne, RB |
en |
| dc.contributor.author |
Mytle, N |
en |
| dc.contributor.author |
Doyle, MP |
en |
| dc.date.accessioned |
2014-06-06T06:48:06Z |
|
| dc.date.available |
2014-06-06T06:48:06Z |
|
| dc.date.issued |
2008 |
en |
| dc.identifier.issn |
00199567 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1128/IAI.01366-06 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3962 |
|
| dc.subject.other |
agriculture |
en |
| dc.subject.other |
animal experiment |
en |
| dc.subject.other |
animal model |
en |
| dc.subject.other |
animal tissue |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
dose response |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
food and drug administration |
en |
| dc.subject.other |
Listeria monocytogenes |
en |
| dc.subject.other |
listeriosis |
en |
| dc.subject.other |
nonhuman |
en |
| dc.subject.other |
pregnant woman |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
rhesus monkey |
en |
| dc.subject.other |
risk assessment |
en |
| dc.subject.other |
stillbirth |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Feces |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Fetus |
en |
| dc.subject.other |
Lethal Dose 50 |
en |
| dc.subject.other |
Listeria Infections |
en |
| dc.subject.other |
Listeria monocytogenes |
en |
| dc.subject.other |
Macaca mulatta |
en |
| dc.subject.other |
Placenta |
en |
| dc.subject.other |
Pregnancy |
en |
| dc.subject.other |
Pregnancy Complications, Infectious |
en |
| dc.subject.other |
Stillbirth |
en |
| dc.title |
Dose-response model for Listeria monocytogenes-induced stillbirths in nonhuman primates |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1128/IAI.01366-06 |
en |
| heal.publicationDate |
2008 |
en |
| heal.abstract |
A dose-response model using rhesus monkeys as a surrogate for pregnant women indicates that oral exposure to 107 CFU of Listeria monocytogenes results in about 50% stillbirths. Ten of 33 pregnant rhesus monkeys exposed orally to a single dose of 102 to 1010 CFU of L. monocytogenes had stillbirths. A log-logistic model predicts a dose affecting 50% of animals at 107 CFU, comparable to an estimated 106 CFU based on an outbreak among pregnant women but much less than the extrapolated estimate (1013 CFU) from the FDA-U.S. Department of Agriculture-CDC risk assessment using an exponential curve based on mouse data. Exposure and etiology of the disease are the same in humans and primates but not in mice. This information will aid in risk assessment, assist policy makers, and provide a model for mechanistic studies of L. monocytogenes-induced stillbirths. Copyright © 2008, American Society for Microbiology. All Rights Reserved. |
en |
| heal.journalName |
Infection and Immunity |
en |
| dc.identifier.issue |
2 |
en |
| dc.identifier.volume |
76 |
en |
| dc.identifier.doi |
10.1128/IAI.01366-06 |
en |
| dc.identifier.spage |
726 |
en |
| dc.identifier.epage |
731 |
en |