Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands

dc.contributor.author	Naoum, F	en
dc.contributor.author	Kasiotis, KM	en
dc.contributor.author	Magiatis, P	en
dc.contributor.author	Haroutounian, SA	en
dc.date.accessioned	2014-06-06T06:48:02Z
dc.date.available	2014-06-06T06:48:02Z
dc.date.issued	2007	en
dc.identifier.issn	14203049	en
dc.identifier.uri	http://dx.doi.org/10.3390/12071259	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/3925
dc.subject	Estrogen receptor binding affinity	en
dc.subject	Pyrazoles	en
dc.subject	SERMs	en
dc.subject.other	estrogen receptor alpha	en
dc.subject.other	estrogen receptor beta	en
dc.subject.other	ligand	en
dc.subject.other	nitro derivative	en
dc.subject.other	pyrazole	en
dc.subject.other	pyrazole derivative	en
dc.subject.other	article	en
dc.subject.other	chemistry	en
dc.subject.other	human	en
dc.subject.other	metabolism	en
dc.subject.other	synthesis	en
dc.subject.other	Estrogen Receptor alpha	en
dc.subject.other	Estrogen Receptor beta	en
dc.subject.other	Humans	en
dc.subject.other	Ligands	en
dc.subject.other	Nitro Compounds	en
dc.subject.other	Pyrazoles	en
dc.title	Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands	en
heal.type	journalArticle	en
heal.identifier.primary	10.3390/12071259	en
heal.publicationDate	2007	en
heal.abstract	Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities. © 2007 by MDPI.	en
heal.journalName	Molecules	en
dc.identifier.issue	7	en
dc.identifier.volume	12	en
dc.identifier.doi	10.3390/12071259	en
dc.identifier.spage	1259	en
dc.identifier.epage	1273	en