dc.contributor.author |
Naoum, F |
en |
dc.contributor.author |
Kasiotis, KM |
en |
dc.contributor.author |
Magiatis, P |
en |
dc.contributor.author |
Haroutounian, SA |
en |
dc.date.accessioned |
2014-06-06T06:48:02Z |
|
dc.date.available |
2014-06-06T06:48:02Z |
|
dc.date.issued |
2007 |
en |
dc.identifier.issn |
14203049 |
en |
dc.identifier.uri |
http://dx.doi.org/10.3390/12071259 |
en |
dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3925 |
|
dc.subject |
Estrogen receptor binding affinity |
en |
dc.subject |
Pyrazoles |
en |
dc.subject |
SERMs |
en |
dc.subject.other |
estrogen receptor alpha |
en |
dc.subject.other |
estrogen receptor beta |
en |
dc.subject.other |
ligand |
en |
dc.subject.other |
nitro derivative |
en |
dc.subject.other |
pyrazole |
en |
dc.subject.other |
pyrazole derivative |
en |
dc.subject.other |
article |
en |
dc.subject.other |
chemistry |
en |
dc.subject.other |
human |
en |
dc.subject.other |
metabolism |
en |
dc.subject.other |
synthesis |
en |
dc.subject.other |
Estrogen Receptor alpha |
en |
dc.subject.other |
Estrogen Receptor beta |
en |
dc.subject.other |
Humans |
en |
dc.subject.other |
Ligands |
en |
dc.subject.other |
Nitro Compounds |
en |
dc.subject.other |
Pyrazoles |
en |
dc.title |
Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands |
en |
heal.type |
journalArticle |
en |
heal.identifier.primary |
10.3390/12071259 |
en |
heal.publicationDate |
2007 |
en |
heal.abstract |
Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities. © 2007 by MDPI. |
en |
heal.journalName |
Molecules |
en |
dc.identifier.issue |
7 |
en |
dc.identifier.volume |
12 |
en |
dc.identifier.doi |
10.3390/12071259 |
en |
dc.identifier.spage |
1259 |
en |
dc.identifier.epage |
1273 |
en |