| dc.contributor.author |
Samakovli, D |
en |
| dc.contributor.author |
Thanou, A |
en |
| dc.contributor.author |
Valmas, C |
en |
| dc.contributor.author |
Hatzopoulos, P |
en |
| dc.date.accessioned |
2014-06-06T06:47:47Z |
|
| dc.date.available |
2014-06-06T06:47:47Z |
|
| dc.date.issued |
2007 |
en |
| dc.identifier.issn |
00220957 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1093/jxb/erm191 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3804 |
|
| dc.subject |
Arabidopsis |
en |
| dc.subject |
Genetic analysis |
en |
| dc.subject |
Hsp90 |
en |
| dc.subject |
Phenotypic variation |
en |
| dc.subject |
Stochastic development |
en |
| dc.subject.other |
Gene expression |
en |
| dc.subject.other |
Genetic engineering |
en |
| dc.subject.other |
Parameter estimation |
en |
| dc.subject.other |
Perturbation techniques |
en |
| dc.subject.other |
Signal transduction |
en |
| dc.subject.other |
Arabidopsis |
en |
| dc.subject.other |
Genetic analysis |
en |
| dc.subject.other |
Phenotypic variation |
en |
| dc.subject.other |
Stochastic development |
en |
| dc.subject.other |
Proteins |
en |
| dc.subject.other |
heat shock protein 90 |
en |
| dc.subject.other |
STAT1 protein |
en |
| dc.subject.other |
Arabidopsis |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
gene expression regulation |
en |
| dc.subject.other |
genetics |
en |
| dc.subject.other |
heat |
en |
| dc.subject.other |
metabolism |
en |
| dc.subject.other |
mutation |
en |
| dc.subject.other |
prenatal development |
en |
| dc.subject.other |
statistics |
en |
| dc.subject.other |
Arabidopsis |
en |
| dc.subject.other |
Gene Expression Regulation, Plant |
en |
| dc.subject.other |
Heat |
en |
| dc.subject.other |
HSP90 Heat-Shock Proteins |
en |
| dc.subject.other |
Mutation |
en |
| dc.subject.other |
STAT1 Transcription Factor |
en |
| dc.subject.other |
Stochastic Processes |
en |
| dc.subject.other |
Arabidopsis |
en |
| dc.title |
Hsp90 canalizes developmental perturbation |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1093/jxb/erm191 |
en |
| heal.publicationDate |
2007 |
en |
| heal.abstract |
Stochastic processes are intrinsic phenomena that perturb developmental processes. However, the canalization process restricts the magnitude of perturbation and hence the magnitude of morphological variation during development. Heat-shock protein 90 (Hsp90) chaperones are a class of proteins stabilizing a network of 'client' proteins that are involved in diverse signal transduction pathways affecting development. Here it is reported that a reduction of Hsp90 gene dose creates canalization perturbations that affect many aspects of Arabidopsis development and results in a plethora of morphological alterations. Hence, Hsp90 restricts stochastic phenomena by minimizing perturbations, thereby canalizing development. It is also shown that morphogenesis is determined by three mutually inter-related parameters: genotype, environment, and time. Hsp90 is involved in the interaction of these three parameters which ultimately affect developmental processes. The amount of phenotypic variation upon the reduction of Hsp90 function could be perceived as adaptive and could have an impact on the evolutionary process. © The Author [2007]. Published by Oxford University Press [on behalf of the Society for Experimental Biology]. All rights reserved. |
en |
| heal.journalName |
Journal of Experimental Botany |
en |
| dc.identifier.issue |
13 |
en |
| dc.identifier.volume |
58 |
en |
| dc.identifier.doi |
10.1093/jxb/erm191 |
en |
| dc.identifier.spage |
3513 |
en |
| dc.identifier.epage |
3524 |
en |