| dc.contributor.author |
Douroudis, K |
en |
| dc.contributor.author |
Tarassi, K |
en |
| dc.contributor.author |
Athanassiades, T |
en |
| dc.contributor.author |
Giannakopoulos, F |
en |
| dc.contributor.author |
Kominakis, A |
en |
| dc.contributor.author |
Thalassinos, N |
en |
| dc.contributor.author |
Papasteriades, Ch |
en |
| dc.date.accessioned |
2014-06-06T06:47:47Z |
|
| dc.date.available |
2014-06-06T06:47:47Z |
|
| dc.date.issued |
2007 |
en |
| dc.identifier.issn |
00012815 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1111/j.1399-0039.2007.00833.x |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3803 |
|
| dc.subject |
BMD |
en |
| dc.subject |
HLA |
en |
| dc.subject |
Osteoporosis |
en |
| dc.subject |
Polymorphisms |
en |
| dc.subject.other |
HLA A antigen |
en |
| dc.subject.other |
HLA A1 antigen |
en |
| dc.subject.other |
HLA A2 antigen |
en |
| dc.subject.other |
HLA A24 antigen |
en |
| dc.subject.other |
HLA B antigen |
en |
| dc.subject.other |
HLA B35 antigen |
en |
| dc.subject.other |
HLA B51 antigen |
en |
| dc.subject.other |
HLA B7 antigen |
en |
| dc.subject.other |
HLA B8 antigen |
en |
| dc.subject.other |
HLA C antigen |
en |
| dc.subject.other |
HLA Cw1 antigen |
en |
| dc.subject.other |
HLA CW2 antigen |
en |
| dc.subject.other |
HLA CW3 antigen |
en |
| dc.subject.other |
HLA CW4 antigen |
en |
| dc.subject.other |
HLA Cw5 antigen |
en |
| dc.subject.other |
HLA Cw6 antigen |
en |
| dc.subject.other |
HLA Cw7 antigen |
en |
| dc.subject.other |
HLA DQ antigen |
en |
| dc.subject.other |
HLA DQ2 antigen |
en |
| dc.subject.other |
hla dq5 antigen |
en |
| dc.subject.other |
HLA DQ6 antigen |
en |
| dc.subject.other |
HLA DQ7 antigen |
en |
| dc.subject.other |
HLA DR antigen |
en |
| dc.subject.other |
HLA DR1 antigen |
en |
| dc.subject.other |
HLA DR11 antigen |
en |
| dc.subject.other |
HLA DR13 antigen |
en |
| dc.subject.other |
HLA DR15 antigen |
en |
| dc.subject.other |
HLA DR16 antigen |
en |
| dc.subject.other |
hla dr17 antigen |
en |
| dc.subject.other |
HLA DR4 antigen |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
adult |
en |
| dc.subject.other |
aged |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
bone atrophy |
en |
| dc.subject.other |
bone density |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
forearm |
en |
| dc.subject.other |
genetic predisposition |
en |
| dc.subject.other |
Greece |
en |
| dc.subject.other |
HLA system |
en |
| dc.subject.other |
human |
en |
| dc.subject.other |
immunogenetics |
en |
| dc.subject.other |
major clinical study |
en |
| dc.subject.other |
population genetics |
en |
| dc.subject.other |
postmenopause osteoporosis |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
Alleles |
en |
| dc.subject.other |
Bone Density |
en |
| dc.subject.other |
Case-Control Studies |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Gene Frequency |
en |
| dc.subject.other |
Greece |
en |
| dc.subject.other |
HLA Antigens |
en |
| dc.subject.other |
HLA-B7 Antigen |
en |
| dc.subject.other |
HLA-DQ Antigens |
en |
| dc.subject.other |
HLA-DR Antigens |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Middle Aged |
en |
| dc.subject.other |
Osteoporosis, Postmenopausal |
en |
| dc.subject.other |
Risk Factors |
en |
| dc.title |
HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1111/j.1399-0039.2007.00833.x |
en |
| heal.publicationDate |
2007 |
en |
| heal.abstract |
It is well established that genetic factors play an important role in the pathogenesis of osteoporosis, a common condition characterized by reduced bone mass and increased fracture risk. The major histocompatibility complex in humans, known as human leukocyte antigen (HLA) region, is the most polymorphic human genetic system and it is known as a cluster of genetic markers, associated with several diseases. In order to evaluate the contribution of HLA alleles in bone mass loss, polymorphisms in the HLA class I (-A, -B and -Cw) and class II (-DR and -DQ) antigens were studied in 126 postmenopausal women of Greek origin. It was found that HLA-B7 (P = 0.069), -DR15 (P = 0.019) and -DQ6 (P = 0.026) were associated with a lower bone mineral density measured at the forearm. This study shows a significant association between HLA alleles and bone mass loss in the population studied. © 2007 Blackwell Munksgaard. |
en |
| heal.journalName |
Tissue Antigens |
en |
| dc.identifier.issue |
6 |
en |
| dc.identifier.volume |
69 |
en |
| dc.identifier.doi |
10.1111/j.1399-0039.2007.00833.x |
en |
| dc.identifier.spage |
592 |
en |
| dc.identifier.epage |
596 |
en |