| dc.contributor.author |
Walker, SM |
en |
| dc.contributor.author |
Prodohl, PA |
en |
| dc.contributor.author |
Fletcher, HL |
en |
| dc.contributor.author |
Hanna, REB |
en |
| dc.contributor.author |
Kantzoura, V |
en |
| dc.contributor.author |
Hoey, EM |
en |
| dc.contributor.author |
Trudgett, A |
en |
| dc.date.accessioned |
2014-06-06T06:47:45Z |
|
| dc.date.available |
2014-06-06T06:47:45Z |
|
| dc.date.issued |
2007 |
en |
| dc.identifier.issn |
09320113 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1007/s00436-006-0440-4 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3784 |
|
| dc.subject |
Drug resistance |
en |
| dc.subject |
Fasciolosis |
en |
| dc.subject |
Genetic diversity |
en |
| dc.subject |
Liver fluke |
en |
| dc.subject |
PCR-RFLP |
en |
| dc.subject |
Population structure |
en |
| dc.subject.other |
antibiotic resistance |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
cattle disease |
en |
| dc.subject.other |
climate change |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
Fasciola hepatica |
en |
| dc.subject.other |
fascioliasis |
en |
| dc.subject.other |
genetic line |
en |
| dc.subject.other |
genetic variability |
en |
| dc.subject.other |
haplotype |
en |
| dc.subject.other |
mitochondrial gene |
en |
| dc.subject.other |
nonhuman |
en |
| dc.subject.other |
nucleotide sequence |
en |
| dc.subject.other |
polymerase chain reaction |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
restriction fragment length polymorphism |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Cattle |
en |
| dc.subject.other |
Cattle Diseases |
en |
| dc.subject.other |
DNA, Mitochondrial |
en |
| dc.subject.other |
Fasciola hepatica |
en |
| dc.subject.other |
Fascioliasis |
en |
| dc.subject.other |
Greece |
en |
| dc.subject.other |
Haplotypes |
en |
| dc.subject.other |
Ireland |
en |
| dc.subject.other |
Netherlands |
en |
| dc.subject.other |
Polymerase Chain Reaction |
en |
| dc.subject.other |
Polymorphism, Restriction Fragment Length |
en |
| dc.subject.other |
Sheep |
en |
| dc.subject.other |
Sheep Diseases |
en |
| dc.subject.other |
Variation (Genetics) |
en |
| dc.subject.other |
Animalia |
en |
| dc.subject.other |
Bos |
en |
| dc.subject.other |
Fasciola hepatica |
en |
| dc.subject.other |
Ovis aries |
en |
| dc.title |
Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1007/s00436-006-0440-4 |
en |
| heal.publicationDate |
2007 |
en |
| heal.abstract |
The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such drugs will be dependent on the genetic variation present in the F. hepatica gene pool, but this is at present unknown. We have assessed the genetic diversity of mitochondrial haplotypes found in the infrapopulation of flukes recovered from a calf of known provenance and from six other cattle and sheep hosts located in Ireland and four from elsewhere. Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. A consequence of this high level of diversity is that there will be frequent selection for anthelmintic resistance and rapid responses to climatic changes. © 2007 Springer-Verlag. |
en |
| heal.journalName |
Parasitology Research |
en |
| dc.identifier.issue |
1 |
en |
| dc.identifier.volume |
101 |
en |
| dc.identifier.doi |
10.1007/s00436-006-0440-4 |
en |
| dc.identifier.spage |
117 |
en |
| dc.identifier.epage |
125 |
en |