Perfluorooctanoic acid and perfluorononanoic acid in fetal and neonatal mice following in utero exposure to 8-2 fluorotelomer alcohol

dc.contributor.author	Henderson, WM	en
dc.contributor.author	Smith, MA	en
dc.date.accessioned	2014-06-06T06:47:26Z
dc.date.available	2014-06-06T06:47:26Z
dc.date.issued	2007	en
dc.identifier.issn	10966080	en
dc.identifier.uri	http://dx.doi.org/10.1093/toxsci/kfl162	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/3589
dc.subject	Fetal and neonatal distribution	en
dc.subject	Fluorotelomer alcohols (FTOH)	en
dc.subject	PFNA	en
dc.subject	PFOA	en
dc.subject.other	8 2 fluorotelomer alcohol	en
dc.subject.other	alcohol	en
dc.subject.other	perfluoro compound	en
dc.subject.other	perfluorononanoic acid	en
dc.subject.other	perfluorooctanoic acid	en
dc.subject.other	unclassified drug	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	blood level	en
dc.subject.other	controlled study	en
dc.subject.other	female	en
dc.subject.other	fetomaternal transfusion	en
dc.subject.other	fetus	en
dc.subject.other	fetus development	en
dc.subject.other	gas chromatography	en
dc.subject.other	lactation	en
dc.subject.other	liver level	en
dc.subject.other	mass spectrometry	en
dc.subject.other	maternal blood	en
dc.subject.other	mouse	en
dc.subject.other	newborn	en
dc.subject.other	nonhuman	en
dc.subject.other	perinatal period	en
dc.subject.other	prenatal exposure	en
dc.subject.other	teratogenicity	en
dc.subject.other	Animals	en
dc.subject.other	Animals, Newborn	en
dc.subject.other	Body Burden	en
dc.subject.other	Body Weight	en
dc.subject.other	Environmental Pollutants	en
dc.subject.other	Fatty Alcohols	en
dc.subject.other	Female	en
dc.subject.other	Fluorocarbons	en
dc.subject.other	Gestational Age	en
dc.subject.other	Liver	en
dc.subject.other	Mice	en
dc.subject.other	Mice, Inbred Strains	en
dc.subject.other	Octanoic Acids	en
dc.subject.other	Organ Size	en
dc.subject.other	Pregnancy	en
dc.subject.other	Prenatal Exposure Delayed Effects	en
dc.subject.other	Tissue Distribution	en
dc.subject.other	Mus	en
dc.title	Perfluorooctanoic acid and perfluorononanoic acid in fetal and neonatal mice following in utero exposure to 8-2 fluorotelomer alcohol	en
heal.type	journalArticle	en
heal.identifier.primary	10.1093/toxsci/kfl162	en
heal.publicationDate	2007	en
heal.abstract	8-2 Fluorotelomer alcohol (FTOH) and its metabolites, perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA), are developmental toxicants but metabolism and distribution during pregnancy are not known. To examine this, timed-pregnant mice received a single gavage dose (30 mg 8-2 FTOH/kg body weight) on gestational day (GD) 8. Maternal and neonatal serum and liver as well as fetal and neonatal homogenate extracts were analyzed using gas chromatography coupled with mass spectrometry. During gestation (GD9 to GD18), maternal serum and liver concentrations of PFOA decreased from 789 ± 41 to 668 ± 23 ng/ml and from 673 ± 23 to 587 ± 55 ng/g, respectively. PFOA was transferred to the developing fetuses as early as 24-h posttreatment with concentrations increasing from 45 ± 9 ng/g (GD10) to 140 ± 32 ng/g (GD18), while PFNA was quantifiable only at GD18 (31 ± 4 ng/g). Post-partum, maternal serum PFOA concentrations decreased from 451 ± 21 ng/ml postnatal day (PND) 1 to 52 ± 19 ng/ml (PND15) and PFNA concentrations, although fivefold less, exhibited a similar trend. Immediately after birth, pups were cross-fostered with dams that had been treated during gestation with 8-2 FTOH (T) or vehicle (C) resulting in four treatment groups in which the first letter represents in utero (fetal) exposure and the second represents lactational (neonatal) exposure: C/C, T/C, C/T, T/T. On PND1, neonatal whole-body homogenate concentrations of PFOA from T/T and T/C groups averaged 200 ± 26 ng/g, decreased to 149 ± 19 ng/g at PND3 and this decreasing trend was seen in both neonatal liver and serum from PND3 to PND15. Based on detectible amounts of PFOA in neonatal serum in the C/T group on PND3 (57 ± 11 ng/ml) and on PND15 (58 ± 3 ng/ml), we suggest that the neonates were exposed through lactation. In conclusion, exposure of neonates to PFOA and PFNA occurs both pre- and postnatally following maternal 8-2 FTOH exposure on GD8. © 2007 Oxford University Press.	en
heal.journalName	Toxicological Sciences	en
dc.identifier.issue	2	en
dc.identifier.volume	95	en
dc.identifier.doi	10.1093/toxsci/kfl162	en
dc.identifier.spage	452	en
dc.identifier.epage	461	en