| dc.contributor.author |
Kasiotis, KM |
en |
| dc.contributor.author |
Fokialakis, N |
en |
| dc.contributor.author |
Haroutounian, SA |
en |
| dc.date.accessioned |
2014-06-06T06:47:15Z |
|
| dc.date.available |
2014-06-06T06:47:15Z |
|
| dc.date.issued |
2006 |
en |
| dc.identifier.issn |
00397881 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1055/s-2006-926466 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3481 |
|
| dc.subject |
Acylations |
en |
| dc.subject |
Estrogens |
en |
| dc.subject |
Fused ring-systems |
en |
| dc.subject |
Pyrazole |
en |
| dc.subject |
Quinolines |
en |
| dc.subject.other |
Conformations |
en |
| dc.subject.other |
Derivatives |
en |
| dc.subject.other |
Esterification |
en |
| dc.subject.other |
Esters |
en |
| dc.subject.other |
Ketones |
en |
| dc.subject.other |
Molecular structure |
en |
| dc.subject.other |
Synthesis (chemical) |
en |
| dc.subject.other |
Acylations |
en |
| dc.subject.other |
Estrogens |
en |
| dc.subject.other |
Fused ring systems |
en |
| dc.subject.other |
Pyrazole |
en |
| dc.subject.other |
Quinolines |
en |
| dc.subject.other |
Sulfur compounds |
en |
| dc.subject.other |
1 (4 hydroxyphenyl) 1h pyrazolo[4,3 c]quinolin 7 ol |
en |
| dc.subject.other |
1 (4 methoxyphenyl) 1h pyrazol[4,3 c]quinolin 7 ol |
en |
| dc.subject.other |
2 (4 hydroxyphenyl) 3 methyl 2h pyrazolo[4,3 c]quinolin 7 ol |
en |
| dc.subject.other |
2 (4 hydroxyphenyl) 3,4 dimethyl 2h pyrazolo[4,3 c]quinolin 7 ol |
en |
| dc.subject.other |
3 methyl 2 phenyl 2h pyrazolo[4,3 c]quinolin 7 ol |
en |
| dc.subject.other |
5 benzyl 7 methoxy 1 (4 methoxyphenyl) 3 phenyl 4,5 dihydro 1h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
5 benzyl 7 methoxy 1 (4 methoxyphenyl) 4 methyl 4,5 dihydro 1h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
5 benzyl 7 methoxy 1 (4 methoxyphenyl) 4,5 dihydro 1h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
5 benzyl 7 methoxy 1 phenyl 4,5 dihydro 1h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
5 benzyl 7 methoxy 1,3 diphenyl 4,5 dihydro 1h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
5 benzyl 7 methoxy 2 (4 methoxyphenyl) 3 phenyl 4,5 dihydro 2h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
5 benzyl 7 methoxy 2 (4 methoxyphenyl) 4,5 dihydro 2h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
5 benzyl 7 methoxy 2,3 diphenyl 4,5 dihydro 2h pyrazolo[4,3 c]quinoline |
en |
| dc.subject.other |
estrogen receptor |
en |
| dc.subject.other |
ligand |
en |
| dc.subject.other |
pyrazole derivative |
en |
| dc.subject.other |
quinoline derivative |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
debenzylation |
en |
| dc.subject.other |
demethylation |
en |
| dc.subject.other |
polymerization |
en |
| dc.subject.other |
stereochemistry |
en |
| dc.subject.other |
synthesis |
en |
| dc.title |
Synthesis of novel conformationally constrained pyrazolo[4,3-c]quinoline derivatives as potential ligands for the estrogen receptor |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1055/s-2006-926466 |
en |
| heal.publicationDate |
2006 |
en |
| heal.abstract |
The preparation of three novel classes of pyrazolo[4,3-c]quinoline derivatives is reported. The easily accessible 2,3-dihydro-1H-quinolin-4-ones were used as the starting materials and were functionalized with three different acylating agents affording their respective constrained core substrates. The latter by condensation with phenyl(or 4-methoxyphenyl)hydrazines and subsequent debenzylation or demethylation provided the desired pyrazole derivatives. Some interesting features emerged with respect to the regioselectivity and mechanism of these reactions. © Georg Thieme Verlag Stuttgart. |
en |
| heal.journalName |
Synthesis |
en |
| dc.identifier.issue |
11 |
en |
| dc.identifier.doi |
10.1055/s-2006-926466 |
en |
| dc.identifier.spage |
1791 |
en |
| dc.identifier.epage |
1802 |
en |