| dc.contributor.author |
Sechi, LA |
en |
| dc.contributor.author |
Gazouli, M |
en |
| dc.contributor.author |
Sieswerda, LE |
en |
| dc.contributor.author |
Molicotti, P |
en |
| dc.contributor.author |
Ahmed, N |
en |
| dc.contributor.author |
Ikonomopoulos, J |
en |
| dc.contributor.author |
Scanu, AM |
en |
| dc.contributor.author |
Paccagnini, D |
en |
| dc.contributor.author |
Zanetti, S |
en |
| dc.date.accessioned |
2014-06-06T06:47:12Z |
|
| dc.date.available |
2014-06-06T06:47:12Z |
|
| dc.date.issued |
2006 |
en |
| dc.identifier.issn |
10079327 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3456 |
|
| dc.relation.uri |
http://www.scopus.com/inward/record.url?eid=2-s2.0-33845399126&partnerID=40&md5=b4bd0e447fc559c5a8bd2e11f652be26 |
en |
| dc.subject |
Crohn's disease |
en |
| dc.subject |
Mycobacterium avium subspecies paratuberculosis |
en |
| dc.subject |
SCL11A1 polymorphisms |
en |
| dc.subject.other |
membrane protein |
en |
| dc.subject.other |
solute carrier 11A1 |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
bacterium identification |
en |
| dc.subject.other |
clinical article |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
correlation analysis |
en |
| dc.subject.other |
Crohn disease |
en |
| dc.subject.other |
gene locus |
en |
| dc.subject.other |
gene sequence |
en |
| dc.subject.other |
genetic association |
en |
| dc.subject.other |
genetic polymorphism |
en |
| dc.subject.other |
genetic susceptibility |
en |
| dc.subject.other |
genetic variability |
en |
| dc.subject.other |
human |
en |
| dc.subject.other |
human tissue |
en |
| dc.subject.other |
logistic regression analysis |
en |
| dc.subject.other |
mycobacteriosis |
en |
| dc.subject.other |
Mycobacterium paratuberculosis |
en |
| dc.subject.other |
pathophysiology |
en |
| dc.subject.other |
polymerase chain reaction |
en |
| dc.subject.other |
risk assessment |
en |
| dc.subject.other |
risk factor |
en |
| dc.subject.other |
Case-Control Studies |
en |
| dc.subject.other |
Cation Transport Proteins |
en |
| dc.subject.other |
Crohn Disease |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Italy |
en |
| dc.subject.other |
Mycobacterium avium |
en |
| dc.subject.other |
Polymorphism, Genetic |
en |
| dc.title |
Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients |
en |
| heal.type |
journalArticle |
en |
| heal.publicationDate |
2006 |
en |
| heal.abstract |
Aim: To study the association between Crohn's disease (CD), Mycobacterium avium subspecies paratuberculosis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sardinian patients with CD and controls. Methods: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written consent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to calculate odds ratios (OR) for the associations among CD, presence of MAP, and 6 loci described above. Results: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated with both NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. Conclusion: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of genetic, infectious, and immunologic factors in the etiology of CD is complex. © 2006 The WJG Press. All rights reserved. |
en |
| heal.journalName |
World Journal of Gastroenterology |
en |
| dc.identifier.issue |
44 |
en |
| dc.identifier.volume |
12 |
en |
| dc.identifier.spage |
7161 |
en |
| dc.identifier.epage |
7164 |
en |