| dc.contributor.author |
Kasiotis, KM |
en |
| dc.contributor.author |
Haroutounian, SA |
en |
| dc.date.accessioned |
2014-06-06T06:46:57Z |
|
| dc.date.available |
2014-06-06T06:46:57Z |
|
| dc.date.issued |
2006 |
en |
| dc.identifier.issn |
00452068 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/j.bioorg.2005.10.005 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3321 |
|
| dc.subject |
Cyclization |
en |
| dc.subject |
Estrogen receptor |
en |
| dc.subject |
Fluorescence |
en |
| dc.subject |
Indoles |
en |
| dc.subject.other |
2 pyridinyl 1h indole derivative |
en |
| dc.subject.other |
estrogen receptor |
en |
| dc.subject.other |
indole derivative |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
binding affinity |
en |
| dc.subject.other |
chemical reaction |
en |
| dc.subject.other |
chemical structure |
en |
| dc.subject.other |
chemistry |
en |
| dc.subject.other |
complex formation |
en |
| dc.subject.other |
fluorescence |
en |
| dc.subject.other |
pH |
en |
| dc.subject.other |
polarization |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
spectroscopy |
en |
| dc.subject.other |
synthesis |
en |
| dc.subject.other |
Binding, Competitive |
en |
| dc.subject.other |
Hydrogen-Ion Concentration |
en |
| dc.subject.other |
Indoles |
en |
| dc.subject.other |
Light |
en |
| dc.subject.other |
Photochemistry |
en |
| dc.subject.other |
Pyridines |
en |
| dc.subject.other |
Receptors, Estrogen |
en |
| dc.subject.other |
Spectrometry, Fluorescence |
en |
| dc.subject.other |
Structure-Activity Relationship |
en |
| dc.title |
2-Pyridin-2-yl-1H-indole derivatives: Synthesis, estrogen receptor binding affinity, and photophysical properties |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/j.bioorg.2005.10.005 |
en |
| heal.publicationDate |
2006 |
en |
| heal.abstract |
A series of novel 2-pyridin-2-yl-1H-indole derivatives (4a-f) was prepared by intramolecular cyclodehydration of α-anilinyl (or 3-anisidyl)-2- pyridin-2-yl-ethanones (2a-f) and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. These compounds showed long wavelength fluorescent emission, which is sensitive to solvent polarity and pH, while indol-6-ols 4b, e, and f displayed reasonably good binding affinities to ER. © 2005 Elsevier Inc. All rights reserved. |
en |
| heal.journalName |
Bioorganic Chemistry |
en |
| dc.identifier.issue |
1 |
en |
| dc.identifier.volume |
34 |
en |
| dc.identifier.doi |
10.1016/j.bioorg.2005.10.005 |
en |
| dc.identifier.spage |
1 |
en |
| dc.identifier.epage |
14 |
en |