| dc.contributor.author |
Politis, I |
en |
| dc.contributor.author |
Fegeros, K |
en |
| dc.contributor.author |
Nitsch, S |
en |
| dc.contributor.author |
Schatzmayr, G |
en |
| dc.contributor.author |
Kantas, D |
en |
| dc.date.accessioned |
2014-06-06T06:46:42Z |
|
| dc.date.available |
2014-06-06T06:46:42Z |
|
| dc.date.issued |
2005 |
en |
| dc.identifier.issn |
00071668 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1080/00071660400023904 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3141 |
|
| dc.subject.other |
ochratoxin |
en |
| dc.subject.other |
superoxide |
en |
| dc.subject.other |
urokinase |
en |
| dc.subject.other |
animal |
en |
| dc.subject.other |
animal disease |
en |
| dc.subject.other |
animal food |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
bird disease |
en |
| dc.subject.other |
chemically induced disorder |
en |
| dc.subject.other |
chicken |
en |
| dc.subject.other |
drug antagonism |
en |
| dc.subject.other |
drug effect |
en |
| dc.subject.other |
immunology |
en |
| dc.subject.other |
macrophage |
en |
| dc.subject.other |
metabolism |
en |
| dc.subject.other |
mycotoxicosis |
en |
| dc.subject.other |
physiology |
en |
| dc.subject.other |
Trichosporon |
en |
| dc.subject.other |
Animal Feed |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Chickens |
en |
| dc.subject.other |
Macrophages |
en |
| dc.subject.other |
Mycotoxicosis |
en |
| dc.subject.other |
Ochratoxins |
en |
| dc.subject.other |
Poultry Diseases |
en |
| dc.subject.other |
Superoxides |
en |
| dc.subject.other |
Trichosporon |
en |
| dc.subject.other |
Urinary Plasminogen Activator |
en |
| dc.subject.other |
Aves |
en |
| dc.subject.other |
Gallus gallus |
en |
| dc.subject.other |
Trichosporon mycotoxinivorans |
en |
| dc.title |
Use of Trichosporon mycotoxinivorans to suppress the effects of ochratoxicosis on the immune system of broiler chicks |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1080/00071660400023904 |
en |
| heal.publicationDate |
2005 |
en |
| heal.abstract |
1. The objective of this study was to determine whether the dietary inclusion of Trichosporon mycotoxinivorans (TRM) could suppress the detrimental effects of ochratoxin A (OTA) on the immune system of broiler chicks. 2. Six experimental treatments were tested in 300 1-d-old broiler chicks. Treatments included addition to a standard broiler ration of neither OTA nor TRM (Diet 1), OTA alone (500 μg/kg), OTA plus TRM at three inclusion rates (10 4CFU/g of feed, 105CFU/g, 106CFU/g) and TRM alone at 105CFU/g of feed. The ration was fed to chicks for 42 d. 3. Blood samples were collected at d 10, 20, 30 and 40 and macrophages and heterophils were isolated. The following variables were determined in macrophages and heterophils activated by phorbol myristate acetate (65 μM): cell viability, total cell-associated urokinase-plasminogen activator (u-PA), membrane-bound u-PA, free u-PA binding sites and superoxide production. 4. There was a decrease in the viability of macrophages and heterophils from chicks receiving OTA-contaminated feed compared to the viability of cells from control birds at d 40. Dietary TRM completely blocked the effect of OTA on cell viability; all three inclusion rates were equally effective. There was a decrease in total cell-associated and membrane-bound u-PA in macrophages and heterophils of chicks receiving OTA-contaminated feed compared to the corresponding values in control birds for heterophils at d 30 and 40 and for the macrophages at d 40. 5. Similarly, dietary TRM abolished the effect of OTA on total cell-associated and membrane-bound u-PA activity. All three inclusion rates of yeast were equally effective. Heterophils, but not macrophages, isolated from chicks receiving OTA-contaminated diet produced less superoxide anion compared to all other diet groups at d 30 and 40. 6. The immune system is a primary target of OTA toxicity in broilers: several functional properties of macrophages and heterophils were depressed in chicks fed OTA-contaminated feed. There was a delay of 30 d before the immunosuppressive effect became apparent. The dietary inclusion of TRM completely blocked the detrimental effects of OTA on several immune properties in broilers. © 2005 British Poultry Science Ltd. |
en |
| heal.journalName |
British Poultry Science |
en |
| dc.identifier.issue |
1 |
en |
| dc.identifier.volume |
46 |
en |
| dc.identifier.doi |
10.1080/00071660400023904 |
en |
| dc.identifier.spage |
58 |
en |
| dc.identifier.epage |
65 |
en |