| dc.contributor.author |
Couladouros, EA |
en |
| dc.contributor.author |
Magos, AD |
en |
| dc.date.accessioned |
2014-06-06T06:46:39Z |
|
| dc.date.available |
2014-06-06T06:46:39Z |
|
| dc.date.issued |
2005 |
en |
| dc.identifier.issn |
13811991 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1007/s11030-005-1295-9 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3120 |
|
| dc.subject |
2,5-diketopiperazines |
en |
| dc.subject |
Amino acids |
en |
| dc.subject |
Combinatorial chemistry |
en |
| dc.subject |
Horner-Emmons reaction |
en |
| dc.subject |
Library |
en |
| dc.subject |
Natural products |
en |
| dc.subject |
Solid-phase synthesis |
en |
| dc.subject.other |
amine |
en |
| dc.subject.other |
amino acid |
en |
| dc.subject.other |
aurantiamine |
en |
| dc.subject.other |
benzene derivative |
en |
| dc.subject.other |
dehydro 2,5 diketopiperazine |
en |
| dc.subject.other |
glycine derivative |
en |
| dc.subject.other |
glycine phosphonate |
en |
| dc.subject.other |
imidazole derivative |
en |
| dc.subject.other |
indole derivative |
en |
| dc.subject.other |
phenylhistine |
en |
| dc.subject.other |
phosphonic acid derivative |
en |
| dc.subject.other |
piperazine derivative |
en |
| dc.subject.other |
pyridine derivative |
en |
| dc.subject.other |
thiazole |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
combinatorial chemistry |
en |
| dc.subject.other |
drug structure |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
solid |
en |
| dc.subject.other |
Indicators and Reagents |
en |
| dc.subject.other |
Models, Molecular |
en |
| dc.subject.other |
Molecular Conformation |
en |
| dc.subject.other |
Piperazines |
en |
| dc.subject.other |
Spectroscopy, Fourier Transform Infrared |
en |
| dc.title |
Solid-phase total synthesis of (-)-Phenylhistine and (-)-Aurantiamine. Synthesis of a diverse dehydro-2,5-diketopiperazine library. Part II |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1007/s11030-005-1295-9 |
en |
| heal.publicationDate |
2005 |
en |
| heal.abstract |
The preparation of solid supported glycine phosphonate and its utilization for the total synthesis of two natural products is presented. The proposed protocol combines diversity with accessibility and speed, which makes this scaffold suitable for automated parallel synthesis and combinatorial chemistry. The preparation of a small library of dehydro-2,5-diketopiperazines, combining several natural amino acids with diverse heterocycles (including thiazoles, pyridines, indoles and imidazoles), is also demonstrated. © Springer 2005. |
en |
| heal.journalName |
Molecular Diversity |
en |
| dc.identifier.issue |
1-3 |
en |
| dc.identifier.volume |
9 |
en |
| dc.identifier.doi |
10.1007/s11030-005-1295-9 |
en |
| dc.identifier.spage |
111 |
en |
| dc.identifier.epage |
121 |
en |