| dc.contributor.author |
Sechi, LA |
en |
| dc.contributor.author |
Gazouli, M |
en |
| dc.contributor.author |
Ikonomopoulos, J |
en |
| dc.contributor.author |
Lukas, JC |
en |
| dc.contributor.author |
Scanu, AM |
en |
| dc.contributor.author |
Ahmed, N |
en |
| dc.contributor.author |
Fadda, G |
en |
| dc.contributor.author |
Zanetti, S |
en |
| dc.date.accessioned |
2014-06-06T06:46:35Z |
|
| dc.date.available |
2014-06-06T06:46:35Z |
|
| dc.date.issued |
2005 |
en |
| dc.identifier.issn |
00951137 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1128/JCM.43.10.5275-5277.2005 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/3091 |
|
| dc.subject.other |
caspase recruitment domain protein 15 |
en |
| dc.subject.other |
allele |
en |
| dc.subject.other |
allelism |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
Crohn disease |
en |
| dc.subject.other |
disease predisposition |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
genetic analysis |
en |
| dc.subject.other |
genetic predisposition |
en |
| dc.subject.other |
genetic susceptibility |
en |
| dc.subject.other |
genetic variability |
en |
| dc.subject.other |
human |
en |
| dc.subject.other |
major clinical study |
en |
| dc.subject.other |
male |
en |
| dc.subject.other |
Mycobacterium avium |
en |
| dc.subject.other |
Mycobacterium paratuberculosis |
en |
| dc.subject.other |
nucleotide sequence |
en |
| dc.subject.other |
priority journal |
en |
| dc.subject.other |
Crohn Disease |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Genetic Predisposition to Disease |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Intracellular Signaling Peptides and Proteins |
en |
| dc.subject.other |
Italy |
en |
| dc.subject.other |
Male |
en |
| dc.subject.other |
Mycobacterium paratuberculosis |
en |
| dc.subject.other |
Nod2 Signaling Adaptor Protein |
en |
| dc.subject.other |
Paratuberculosis |
en |
| dc.subject.other |
Mycobacterium avium |
en |
| dc.subject.other |
Mycobacterium avium subsp. paratuberculosis |
en |
| dc.title |
Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: The way ahead |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1128/JCM.43.10.5275-5277.2005 |
en |
| heal.publicationDate |
2005 |
en |
| heal.abstract |
The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD2/CARD15 gene (insC3020, G908R, and R702W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD2/CARD15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis. Copyright © 2005, American Society for Microbiology. All Rights Reserved. |
en |
| heal.journalName |
Journal of Clinical Microbiology |
en |
| dc.identifier.issue |
10 |
en |
| dc.identifier.volume |
43 |
en |
| dc.identifier.doi |
10.1128/JCM.43.10.5275-5277.2005 |
en |
| dc.identifier.spage |
5275 |
en |
| dc.identifier.epage |
5277 |
en |