| dc.contributor.author |
Michelotti, E |
en |
| dc.contributor.author |
Moffett, K |
en |
| dc.contributor.author |
Nguyen, D |
en |
| dc.contributor.author |
Kelly, M |
en |
| dc.contributor.author |
Shetty, R |
en |
| dc.contributor.author |
Chai, X |
en |
| dc.contributor.author |
Northrop, K |
en |
| dc.contributor.author |
Namboodiri, V |
en |
| dc.contributor.author |
Campbell, B |
en |
| dc.contributor.author |
Flynn, G |
en |
| dc.contributor.author |
Fujimoto, T |
en |
| dc.contributor.author |
Hollinger, F |
en |
| dc.contributor.author |
Bukhtiyarova, M |
en |
| dc.contributor.author |
Springman, E |
en |
| dc.contributor.author |
Karpusas, M |
en |
| dc.date.accessioned |
2014-06-06T06:46:24Z |
|
| dc.date.available |
2014-06-06T06:46:24Z |
|
| dc.date.issued |
2005 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/j.bmcl.2005.08.038 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2984 |
|
| dc.subject |
Binding Site |
en |
| dc.subject |
Biological Activity |
en |
| dc.subject |
Map Kinase |
en |
| dc.title |
Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/j.bmcl.2005.08.038 |
en |
| heal.publicationDate |
2005 |
en |
| heal.abstract |
Two new classes of diphenylether inhibitors of p38α MAP kinase are described. Both chemical classes are based on a common diphenylether core that is identified by simulated fragment annealing as one of the most favored chemotypes within a prominent hydrophobic pocket of the p38α ATP-binding site. In the fully elaborated molecules, the diphenylether moiety acts as an anchor occupying the |
en |
| heal.journalName |
Bioorganic & Medicinal Chemistry Letters |
en |
| dc.identifier.doi |
10.1016/j.bmcl.2005.08.038 |
en |