| dc.contributor.author |
Rotas, G |
en |
| dc.contributor.author |
Natchkebia, K |
en |
| dc.contributor.author |
Natsvlishvili, N |
en |
| dc.contributor.author |
Kekelidze, M |
en |
| dc.contributor.author |
Kimbaris, A |
en |
| dc.contributor.author |
Varvounis, G |
en |
| dc.contributor.author |
Mikeladze, D |
en |
| dc.date.accessioned |
2014-06-06T06:46:19Z |
|
| dc.date.available |
2014-06-06T06:46:19Z |
|
| dc.date.issued |
2005 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/j.bmcl.2005.05.006 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2917 |
|
| dc.subject |
Glial Cell |
en |
| dc.title |
Action of a novel pyrrolo[1,2- c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/j.bmcl.2005.05.006 |
en |
| heal.publicationDate |
2005 |
en |
| heal.abstract |
We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 were manifested with both non-transformed primary neuronal/glial cells and transformed Jurkat cells. The other compounds did not change the viability either |
en |
| heal.journalName |
Bioorganic & Medicinal Chemistry Letters |
en |
| dc.identifier.doi |
10.1016/j.bmcl.2005.05.006 |
en |