| dc.contributor.author |
Magrioti, V |
en |
| dc.contributor.author |
Verger, R |
en |
| dc.contributor.author |
Constantinou-Kokotou, V |
en |
| dc.date.accessioned |
2014-06-06T06:46:10Z |
|
| dc.date.available |
2014-06-06T06:46:10Z |
|
| dc.date.issued |
2004 |
en |
| dc.identifier.issn |
00222623 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1021/jm034202s |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2818 |
|
| dc.subject.other |
2 (n tert butoxycarbonylamino)oleic acid |
en |
| dc.subject.other |
2 methylglycerol |
en |
| dc.subject.other |
enzyme inhibitor |
en |
| dc.subject.other |
oleic acid |
en |
| dc.subject.other |
triacylglycerol |
en |
| dc.subject.other |
triacylglycerol lipase |
en |
| dc.subject.other |
triolein |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
aqueous solution |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
drug structure |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
enzyme inhibition |
en |
| dc.subject.other |
hydrolysis |
en |
| dc.subject.other |
surface tension |
en |
| dc.subject.other |
Humans |
en |
| dc.subject.other |
Lipase |
en |
| dc.subject.other |
Oleic Acids |
en |
| dc.subject.other |
Pancreas |
en |
| dc.subject.other |
Stomach |
en |
| dc.subject.other |
Structure-Activity Relationship |
en |
| dc.subject.other |
Triglycerides |
en |
| dc.title |
Triacylglycerols Based on 2-(N-tert-Butoxycarbonylamino)oleic Acid Are Potent Inhibitors of Pancreatic Lipase |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1021/jm034202s |
en |
| heal.publicationDate |
2004 |
en |
| heal.abstract |
A novel class of potent human pancreatic lipase (HPL) inhibitors was developed. Triacylglycerol analogues containing 2-(N-tert-butoxycarbonylamino) fatty acids were synthesized, and their ability to form stable films at the air/ water interface was studied. The inhibition of human digestive lipases by the compounds synthesized was studied by the monolayer technique, and the triesters of glycerol and 2-methylglycerol with 2-(N-tert-butoxycarbonylamino)oleic acid were found to be potent inhibitors of HPL. |
en |
| heal.journalName |
Journal of Medicinal Chemistry |
en |
| dc.identifier.issue |
2 |
en |
| dc.identifier.volume |
47 |
en |
| dc.identifier.doi |
10.1021/jm034202s |
en |
| dc.identifier.spage |
288 |
en |
| dc.identifier.epage |
291 |
en |