Synthetic studies towards oxazinins. An expedient first total synthesis and proof of the absolute stereochemistry of oxazinin-3

dc.contributor.author	Couladouros, EA	en
dc.contributor.author	Moutsos, VI	en
dc.contributor.author	Pitsinos, EN	en
dc.date.accessioned	2014-06-06T06:46:08Z
dc.date.available	2014-06-06T06:46:08Z
dc.date.issued	2004	en
dc.identifier.issn	00404039	en
dc.identifier.uri	http://dx.doi.org/10.1016/j.tetlet.2004.08.054	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/2805
dc.subject	3-Methyleneindolenine	en
dc.subject	Morpholinone	en
dc.subject	Oxazinins	en
dc.subject	Total synthesis	en
dc.subject.other	3 methyleneindolenine	en
dc.subject.other	hydroxyl group	en
dc.subject.other	indole derivative	en
dc.subject.other	marine toxin	en
dc.subject.other	oxazine derivative	en
dc.subject.other	oxazinin 1	en
dc.subject.other	oxazinin 2	en
dc.subject.other	oxazinin 3	en
dc.subject.other	unclassified drug	en
dc.subject.other	addition reaction	en
dc.subject.other	article	en
dc.subject.other	chemical analysis	en
dc.subject.other	molecule	en
dc.subject.other	stereochemistry	en
dc.subject.other	synthesis	en
dc.title	Synthetic studies towards oxazinins. An expedient first total synthesis and proof of the absolute stereochemistry of oxazinin-3	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.tetlet.2004.08.054	en
heal.publicationDate	2004	en
heal.abstract	A synthetic strategy, based on intramolecular addition of an appropriate hydroxyl substituent to a 3-methyleneindolenine, towards the naturally occurring marine toxins oxazinin-1, -2 and -3 is presented. The expedient first total synthesis of oxazinin-3, thus accomplished, demonstrated the efficiency of the approach and established the absolute stereochemistry of oxazinin-3 as 2S,5S. © 2004 Elsevier Ltd. All rights reserved.	en
heal.journalName	Tetrahedron Letters	en
dc.identifier.issue	41	en
dc.identifier.volume	45	en
dc.identifier.doi	10.1016/j.tetlet.2004.08.054	en
dc.identifier.spage	7779	en
dc.identifier.epage	7781	en