| dc.contributor.author |
Fragou, S |
en |
| dc.contributor.author |
Fegeros, K |
en |
| dc.contributor.author |
Xylouri, E |
en |
| dc.contributor.author |
Baldi, A |
en |
| dc.contributor.author |
Politis, I |
en |
| dc.date.accessioned |
2014-06-06T06:45:58Z |
|
| dc.date.available |
2014-06-06T06:45:58Z |
|
| dc.date.issued |
2004 |
en |
| dc.identifier.issn |
0931184X |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1111/j.1439-0442.2004.00623.x |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2737 |
|
| dc.subject.other |
Suidae |
en |
| dc.subject.other |
alpha tocopherol |
en |
| dc.subject.other |
cell surface receptor |
en |
| dc.subject.other |
plasminogen activator, urokinase receptors |
en |
| dc.subject.other |
urokinase |
en |
| dc.subject.other |
animal |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
clinical trial |
en |
| dc.subject.other |
controlled clinical trial |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
diet supplementation |
en |
| dc.subject.other |
drug effect |
en |
| dc.subject.other |
macrophage |
en |
| dc.subject.other |
metabolism |
en |
| dc.subject.other |
neutrophil |
en |
| dc.subject.other |
randomized controlled trial |
en |
| dc.subject.other |
swine |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Dietary Supplements |
en |
| dc.subject.other |
Macrophages |
en |
| dc.subject.other |
Neutrophils |
en |
| dc.subject.other |
Receptors, Cell Surface |
en |
| dc.subject.other |
Swine |
en |
| dc.subject.other |
Urinary Plasminogen Activator |
en |
| dc.subject.other |
Vitamin E |
en |
| dc.title |
Effect of vitamin E supplementation on various functional properties of macrophages and neutrophils obtained from weaned piglets |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1111/j.1439-0442.2004.00623.x |
en |
| heal.publicationDate |
2004 |
en |
| heal.abstract |
Sixteen piglets were used to determine the effect of vitamin E supplementation on several functional properties of macrophages and neutrophils obtained from weaned piglets. Piglets, immediately following weaning, were assigned to one of three experimental groups: control (no vitamin E supplementation), low level of vitamin E supplementation (100 mg DL-α-tocopheryl acetate/kg diet) and high level of vitamin E supplementation (300 mg DL-α-tocopheryl acetate/kg diet). Supplementation of vitamin E lasted for a period of 36 days, following a 3-day adaptation period after weaning. Blood samples were collected on days 0, 12, 24 and 36 of the experimental period, monocytes/macrophages and neutrophils were isolated and the following parameters were determined in macrophages and neutrophils activated by phorbol myristate acetate: total cell-associated and membrane-bound urokinase plasminogen activator (u-PA) activity and Superoxide anion production. Results showed that macrophages and neutrophils isolated from piglets that received supplemental vitamin E had higher (P < 0.05) total and membrane-bound u-PA activities as well as higher (P < 0.05) Superoxide anion production compared with the values of the corresponding cells obtained from control piglets on day 12 of the experimental period. Both levels of vitamin E supplementation (low and high) were equally effective. In contrast, vitamin E supplementation had no effect (P > 0.05) on total and membrane-bound u-PA activities and superoxide anion production by porcine macrophages and neutrophils on days 24 and 36 of the experimental period. In conclusion, the low level of vitamin E supplementation is recommended for piglets for the first 2 weeks after weaning. © 2004 Blackwell Verlag. |
en |
| heal.journalName |
Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine |
en |
| dc.identifier.issue |
4 |
en |
| dc.identifier.volume |
51 |
en |
| dc.identifier.doi |
10.1111/j.1439-0442.2004.00623.x |
en |
| dc.identifier.spage |
178 |
en |
| dc.identifier.epage |
183 |
en |